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C-terminal domain of inner kinetochore subunit MCM22 and similar proteins MCM22, also called CENP-K homolog, or constitutive centromere-associated network protein MCM22, or minichromosome maintenance protein 22, is a component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. It is a component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. The model corresponds to the C-terminal domain of MCM22, which interacts with another three kinetochore subunits: CNN1, MCM16 and CTF3.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",