Conserved Protein Domain Family
Kunitz_collagen_alpha6_VI-like
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cd22631: Kunitz_collagen_alpha6_VI-like 
Kunitz-type domain from the alpha6 chain of fish type VI collagen, and similar proteins
This model includes the Kunitz-type domain from the alpha6 chain of type VI collagen (collagen alpha 6(VI) chain) and similar proteins. Collagen VI is a widely expressed member of the triple helix-containing protein superfamily of collagens and forms beaded microfibrils that anchor large interstitial structures. Immediately after fibril formation, the Kunitz domain can be cleaved off. This domain is similar to that of Kunitz-type proteinase inhibitors such as BPTI (bovine pancreatic trypsin inhibitor) that shows an alpha/beta fold with irregular secondary structure stabilized by three disulfide bonds.
Links
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Statistics
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PSSM-Id: 438674
Aligned: 28 rows
Threshold Bit Score: 89.9795
Created: 16-Jul-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_028281023 2389 CLLTKDPGSCQNYTLMWFFDNe-eGRCSRFWYGGCGGNQNRFGTRKECESLC 2439 Indian glassy fish
XP_015247149 2641 CLLNQDPGSCQDYTVMWFFDNk-qNECQRFWFGGCDGNANRFQTKGDCEKLC 2691 sheepshead minnow
KAE8289307   1304 CSLGQDTGSCQDYTMMWFFDSs-qRSCFPFWYGGCGGNENRFKTKQDCEKVC 1354 large yellow croaker
XP_030249650 2414 CLLRQDTGGCQEYTEMWSFDNd-rGRCTRFWYSGCGGNKNRFVTKKDCEKTC 2464 gilthead seabream
XP_015804853 2201 CLLNRNSGQCRKYTIKWFYDSk-qSRCFRFRYGGCGGNRNRFSTQRECEATC 2251 turquoise killifish
XP_015260760  429 CLQNKKSGSCKTFTFMWFYDSk-nARCTRFLYSGCGGNQNRFKTREECEDTC 479  sheepshead minnow
TFK08270     1145 CLEDRDAGPCHSFALKWFFNKtqpARCTPFWYGGCEGNRNRFETQELCESTC 1196 big-headed turtle
XP_027299467 1170 CLEARDAGPCRSYSPKWFFEEp--GRCSLFWYGGCGGSRNRFESREQCEALC 1219 mallard
XP_019719265 2642 CLLGEDAGDCRDYAMMWFYDSe-qRQCKRFWYGGCGGNANRFSTMEACQDAC 2692 tiger tail seahorse
RVE63296     2686 CLQPLDLGSCQDYAKMWFFSSt-eNNCAPFWYGGCGGNQNRFATEEECQNTC 2736 javanese ricefish
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