2WVR,2WVR,4BRY,2ZXX,2ZXX


Conserved Protein Domain Family
geminin_CC
?
cd22589: geminin_CC 
Click on image for an interactive view with Cn3D
central coiled-coil domain of geminin
Geminin, together with geminin coiled-coil domain-containing protein 1 (GemC1) and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. Geminin is an inhibitor of Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC) that function in the duplication of chromosomal DNA. Pre-RC assembly culminates in the recruitment of the hexameric mini-chromosome maintenance complex (MCM) onto chromatin. Geminin tightly binds and sequesters Cdt1 in a complex that is unable to recruit MCM to origins, inhibiting DNA replication. It belongs to the geminin family of proteins that also includes GemC1 and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of geminin.
Links
?
Statistics
?
PSSM-Id: 439143
Aligned: 43 rows
Threshold Bit Score: 69.9389
Created: 8-Oct-2020
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
dimer interfaceCdt1 binding
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:geminin family proteins form homo- and heterodimers between them through their coiled-coil domains; this ability is likely to be important for modulating their function in cycling and differentiating cells
  • Structure:2WVR: Human geminin forms a homodimer; contacts at 4A
  • Structure:4BRY: Human geminin forms a heterodimer with multicilin/Idas; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  ##  #  ## ##  ## ##  ## ##  ## ##  ##  #  ## #   #            
2WVR_A        96 SQYWKEVAEKRRKALYEALKENEKLHKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNG 160 human
XP_027221085 147 PEYWEGLAEKRREALEETLEENHKLHEENTSLKKEVTVLKEENKLLEEMVEEAKGLAEMVQELTG 211 Penaeus vannamei
XP_013407543 140 EAYWKEVAEERRVALAEALEENEKLHSEIKELKEENEQLSSLASQAEYFAGIVKLLTEGGEDEEK 204 Lingula anatina
XP_029635304 102 ETYWKDYSEQQRQALAETLDENKALHEENKQLKAKVEELTIENDMLKHENETLSELASKAEDFAN 166 Octopus sinensis
XP_018647185 110 ENYWETIAEQRRVALKETLDENMELCALVEKLNLEIERLSAIASHADHFASVYNQMFKEQEAHNN 174 Schistosoma mansoni
AFB70998     131 GKYWEELSEERRVALEETLKENEKLFIENQELKEENSKLQVMADQAEYLADVVETLMQRIESTTE 195 painted urchin
KZS21581     119 VEYYSTMAERRRVALAEALEENEQLHLELDSLKSEVNTLKTENSMLKPLADEAEYLAGVLKGLLG 183 Daphnia magna
TNN18481      90 EKYWETIAEQRRVALKETLDENMELCSLVEKLNLEIERLSAIASHADNFASVYYETVRMQEANSN 154 Schistosoma japonicum
XP_022668715 139 VDYWRMIAEQRRVALENALKENRQLHEEVEVLTAENKHLQKIADHCGELAELVKALTADDDEGDN 203 honeybee mite
XP_002405254  96 IQYWKELAEQRRIALEKALQENEELHEQVELLTEENKHLQTIADQALPLAELVKDLTGGKLPRED 160 Ixodes scapularis

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap