5C9N,5C9N


Conserved Protein Domain Family
GemC1_CC
?
cd22588: GemC1_CC 
Click on image for an interactive view with Cn3D
central coiled-coil domain of geminin coiled-coil domain-containing protein 1
Geminin coiled-coil domain-containing protein 1 (GemC1), which, together with McIdas (also called Idas or multicilin) and geminin, controls both the cell cycle and differentiation decisions in cells. GemC1 binds to geminin and is implicated in DNA replication control. It also functions as an early regulator of multiciliogenesis. GemC1 and Idas specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors, resulting in centriole amplification and cilia formation. GemC1 belongs to the geminin family of proteins that also includes geminin and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of GemC1.
Links
?
Statistics
?
PSSM-Id: 439142
Aligned: 50 rows
Threshold Bit Score: 103.006
Created: 8-Oct-2020
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
dimer interface
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:geminin family proteins form homo- and heterodimers between them through their coiled-coil domains; this ability is likely to be important for modulating their function in cycling and differentiating cells
  • Structure:5C9N: Human Geminin coiled-coil domain-containing protein 1 forms a homodimer; contacts at 4.0A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  ## ##  ## ##  ## ##  ## ##  #   #  #  #                   
5C9N_B        10 CSWEEAQLSSQLYRNKQLQDTLVQKEEELARLHEENNHLRQYLNSALVKCEEEKAKKELSS 70  Homo sapiens
TRY92850     140 QHIWHDQLAPQLQRNKQLQDTLMQRDEELARLQEENNKLKEFLNSSYVKSLEEKTKKLLSK 200 Danionella translucida
XP_030631950  70 NPTWADQLSPQLQRNKQLQDTLMQREEELARLQEENNKLKEFLNSSYVKSLQEKSKKFLPI 130 milkfish
XP_007233588  74 DTTWPDQLSPHLQRNRQLQDTLMQKEEELARLQEENNKLKEFLNSSYVKSLEEKSKRLLSA 134 Mexican tetra
KAA0702222    69 HHTWPDQLSPQLQRNKQLQDTLIQREEELAKLQEENNKLKEFLNSSYVKSLEEKSKKLLSN 129 Triplophysa tibetana
XP_028818255  56 DPAWSDHLSPHLQRNKQLQDTLMQREEELARLHEENCKLREFLNSSFVKSLEEKRKKLLSA 116 denticle herring
XP_017564350 162 DSTWPDQMSPHLQRNKQLQDTLIQKEEELARLQEENYKLKEFLNSSYVKSLEEKSKRLSAQ 222 red-bellied piranha
XP_031428787 177 QQTWPDHLSPHFQRNKQLQDTLMQRDEELARLHEENNKLKDFLNSSFVKCLEDKRKKLLNA 237 Atlantic herring
XP_030193071 113 QPEATIKLSPHLHRNKQLQDTLQQREEELARLQQENDKLRHFLSSSFVKNLEEKVKGLSSD 173 Atlantic cod
XP_028818254  79 SVPAGSISLFSQLLKCQLQDTLMQREEELARLHEENCKLREFLNSSFVKSLEEKRKKLLSA 139 denticle herring

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap