6Y3Z,5LOP


Conserved Protein Domain Family
Edc3_Lsm
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cd22576: Edc3_Lsm 
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Lsm domain of enhancer of mRNA-decapping protein 3 (Edc3) and similar proteins
Edc3 is an enhancer that stimulates decapping of both stable and unstable mRNA during mRNA decay. It does not affect nonsense-mediated mRNA decay. Edc3 also acts as a scaffold that aggregates mRNA ribonucleoproteins together for normal P-body assembly. The model corresponds to the N-terminal Lsm domain of Edc3, which is responsible for Dcp2 binding and decapping activation.
Links
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Statistics
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PSSM-Id: 439343
Aligned: 7 rows
Threshold Bit Score: 95.6732
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Dcp2 binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:Dcp2 binding site [polypeptide binding site]
Evidence:
  • Structure:6Y3Z: Saccharomyces cerevisiae Edc3 in complex with Dcp2; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #                  #   ##  #                   ## ## #### # 
6Y3Z_C      9 FVGFGVQVELKDGKLIQGKIAKATSKGLTLNDVQFGDGGKSQAFKVRASRLKDLKVLTVA 68  Saccharomyces cerevisiae S288C
5LOP_C      4 FKGYQIEIELKDGKRITGTLKQVSPKSLTLTDAVFQDGGVSPVFKIKADKLYDLKVLKLP 63  Kluyveromyces lactis NRRL Y-1140
P39998      4 FVGFGVQVELKDGKLIQGKIAKATSKGLTLNDVQFGDGGKSQAFKVRASRLKDLKVLTVA 63  Saccharomyces cerevisiae S288C
NP_010901   4 FVGFGVQVELKDGKLIQGKIAKATSKGLTLNDVQFGDGGKSQAFKVRASRLKDLKVLTVA 63  Saccharomyces cerevisiae S288C
OEJ92482   68 YVGFQVVVQLQDGKEITGTIYKYNGKTLVLSDASFGDGGKAALFKVKANRLKDLKVTEVP 127 Hanseniaspora osmophila
QEU58711    4 FKGYQIEIELKDGKRITGTLKQVSPKSLTLTDAVFQDGGVSPVFKIKADKLYDLKVLKLP 63  Kluyveromyces lactis
XP_449492   4 FIGYGVKLELKDGKILEGKITKATSKGLVLSDVKFEDGGSSQLFKVRSSQLKDLKVVSVR 63

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