7C79,6W6V


Conserved Protein Domain Family
RMP1_RBD
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cd22573: RMP1_RBD 
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RNA binding domain of Saccharomyces cerevisiae RNase MRP protein 1 (RMP1) and similar proteins
RMP1, also called RNA-processing protein RMP1, or RNase MRP 23.6 kDa subunit, functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex. RMP1 is required for proper rRNA processing. The model corresponds to a conserved region of RMP1, which is responsible for the RNA binding.
Links
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Statistics
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PSSM-Id: 439340
Aligned: 176 rows
Threshold Bit Score: 88.0182
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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RNA binding
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:7C79: Saccharomyces cerevisiae ribonuclease MRP protein subunit MP1 interacts with ribonuclease MRP RNA subunit Nme1; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       ## ##  #     #  ## ##   #                                        
7C79_L         8 IRSLEQEYRLILLLNHRNKNQHRaaSWYGSFNEMKRNCGQIITLfssrrlqa---------------------------- 59  Saccharomyces c...
KAA8896829     9 PPALVNEYQIVHLIYYRSRNQHRisTWWKYFSILHRKLRWVVDNp----------------------------------- 53  Diutina rugosa
KAA8917118    11 EAALRSETEILHLIYHRNRNQFKrtKWWTQFSILHRRCWQLVELvetar------------------------------- 59  Trichomonascus ...
KGK38559      25 YLSLLDEFQIIHLVYHRNLNQHHvaKWWSDLDILRRHLRKVLLLihdideirtlrrltgvqwnvgkktfvkvfevpkmte 104 Pichia kudriavz...
EDK39122      16 VDSLRNEYQLMQLTYHRNLNQHRqaRWWRYFNILKRNVSKLLQLfdklqsmpk--------------------------- 68  Meyerozyma guil...
CDO51868      30 FAAFKQETELLHLVLYRSRNQHHvsHWWRYFSMLHQHCFRIVNSyerlvhmrarnssrskpgnkksgssntsn------- 102 Geotrichum cand...
XP_020046419  18 QKLLISELDILSHIYKRNKNQHSssNYWSHINIIYRNLRKIINSlsslnkiinkdsnkdnr------------------- 78  Ascoidea rubesc...
TID14807      24 HEELLNEFRILHLVYHRNKNQHRvaRWWSSLDLLHRHLRKILLImediheilskrrlssilwnenkksyykakefpsqk- 102 [Candida] incon...
XP_019018989  31 YPLLLNEYGIIHLLYHRNLNQHRvsRWWSHLDILHRHTRKILLLledvdeirtlrrltaiqwnsakktfvkvnefpqmvq 110 Pichia membrani...
XP_006684218   8 YDTLINETQVLQLIYHRNKNQHRlsGWWKYFKMLLTRLKRIVKDp----------------------------------- 52  Yamadazyma tenu...

Feature 1                                                                      ##  ##            
7C79_L        60 ---------------------------------------krlkdveWVKLHRLLQRalfrqLKRWYWQFNGVIALGQFvT 100 Saccharomyces c...
KAA8896829    54 ---------------------------------------------eDGVTIRYLRKr---lLPKCYWEFNSMVALGQFiN 85  Diutina rugosa
KAA8917118    60 ------------------------------------------dsdkLKSIVHFLNKk---lIPSAYRSFHNVLAQGQFvT 94  Trichomonascus ...
KGK38559     105 r---------stfkgkkstkrelklkkhnqlddvkavelingklklLFKEVRYLNKk---cIQRCYWSFMGVIELGQFvN 172 Pichia kudriavz...
EDK39122      69 --------------------------------------kastihnkILEICTYLLSrr--iFTKVYFELNTILALGQFiA 108 Meyerozyma guil...
CDO51868     103 ------------------nkrsnnsgknlkgysdysegpvwatskrIQDEAHYLYTk---lIPSARLSFHGILRQGAFvT 161 Geotrichum cand...
XP_020046419  79 ------------------------------kdiskvihkynkindnLINQVLFFKKk---lIPSSYIRFHGVINLGQFiT 125 Ascoidea rubesc...
TID14807     103 ------------kvkrnkknskrnlflhdkftddqginlinkklslMGKEIHYITKq---cIPSAYWQFMGVIELGQFsN 167 [Candida] incon...
XP_019018989 111 krvlkkaslssgsrkgkkkrvekfimlhrkmsdasavslidkklslILKETKYLYKh---iIPASYWNFMGVIELAQFaN 187 Pichia membrani...
XP_006684218  53 ---------------------------------------------iKKNVTVLYQKk---iINKCFYEFYGIIKLGQFmS 84  Yamadazyma tenu...

Feature 1                           
7C79_L       101 LGCTLVTLLANVRALYMRL 119 Saccharomyces cerevisiae S288C
KAA8896829    86 LGIALIGVVAKVDALLAEL 104 Diutina rugosa
KAA8917118    95 LGLAIIALLARIRHLLRPS 113 Trichomonascus ciferrii
KGK38559     173 IGFTVVGALAKVFSLLKQF 191 Pichia kudriavzevii
EDK39122     109 LGFALIAMLARVRTLVLEI 127 Meyerozyma guilliermondii ATCC 6260
CDO51868     162 LGLALLGLAARLHALLEVV 180 Geotrichum candidum
XP_020046419 126 LGLTLIAILSRLSHIFNKI 144 Ascoidea rubescens DSM 1968
TID14807     168 LGFVLIGLTAKINSLLQKF 186 [Candida] inconspicua
XP_019018989 188 IGFALIGFISRTWSLLSKV 206 Pichia membranifaciens NRRL Y-2026
XP_006684218  85 LGLVLVASLSKINEILKAY 103 Yamadazyma tenuis ATCC 10573

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