6L81


Conserved Protein Domain Family
GCP5_NTD
?
cd22572: GCP5_NTD 
Click on image for an interactive view with Cn3D
N-terminal domain of gamma-tubulin complex component 5 (GCP-5) and similar proteins
GCP-5, also called TUBGCP5, is a component of the gamma-tubulin ring complex (gamma-TuRC), which is necessary for microtubule nucleation at the centrosome. The model corresponds to the N-terminal domain (NTD) of GCP-5, which is involved in protein-protein interactions. GCP-5 binds Mozart1, a microprotein that regulates subcellular targeting and microtubule formation activity of gamma-TuRC at different cell cycle stages, through its NTD.
Links
?
Statistics
?
PSSM-Id: 439339
Aligned: 210 rows
Threshold Bit Score: 55.2499
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
heterodimer
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:6L81: Homo sapiens GCP5 N-terminus in complex with Mozart1; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1            #  ##   ##         #  ##  ## ##### ###                   #       #   #  #  ##
6L81_A         20 QERDVRELVRGVAGlqd-eadPNFQLALNFAWSNFRFHRFLdv--nSHKIEKTIEGIYEKFVIHsdLSKAASWKRLTEEF 96   human
XP_002958642  480 VQQLAQVLTQASDP-------ANFDLAFNFVAQNVAELGRSi---dIRAAEDWFDSLARRCDVDsqCGKAARVRALVAEI 549  Volvox carter...
XP_015903396   11 YSENCKLLVKAVTKfdk--tdENFTTCYDHLLSTLLYHTYKea--nSHEAMHIISKFHEKFLIQseLEKANRFKKVSDNL 86   common house ...
XP_017298764   10 FKPYLKYLITHILGlee--ddEDFEQCLEFALSNVLYHHFMcv--dKFKVNSCLNGLVEKFKYHgfINKSKHLKQCKEKF 85   Asian citrus ...
GAX73780       13 RELLLNNLVSHLFPfkp--neENYKTALEYSTSNLNPKYHSfqevrSTDVKELYEELEERLLEHsqLTKAAALSQLRHKL 90   Chlamydomonas...
PNW77310       13 RDVWCRRLVSAYLPglqnqdpANFNIAFSYVSQNLEELAPDa---nPRDAEDWFGSLARRCEEDsqLAKAQRIRQLVTEI 89   Chlamydomonas...
XP_024081715   11 CGPNFEDLVTQITGfek--hsPEFTRCLDSAWHHMFSHYYTsv--nDQDVKQQLLSFWDKFIFHgfTQKAKNLKILVNTY 86   bed bug
RZF37218       12 LRPDLKRLIQHITNftd--ndVGYKQCEAFAFSQLLYHNFLsv--nRLEVQRTIHGLIDKFNIQgfNEKAKTLETLVDKF 87   small brown p...
TRY61968      147 LEGPLSRLITHLTSfqp--eeENYELCHAFAVSNLLYHNYYep--qERTLQGHFEGLAQKFQIHvqRDKEQRLAHLLSAY 222  Tigriopus cal...
GBM74814       11 YGDQCKLLTQSVTGfqe--tdENFQLCLDFAVSNLLYHKYPdv--nCFEIKKKISRLHERFLITsnSKKAESFECVTSKL 86   Araneus ventr...

Feature 1                          ## ### ### 
6L81_A         97 lnaplpsikeiktDAHYSILSLLLCLSD 124  human
XP_002958642  550 kcwgss-lksdydDPEYRILTLLMLLAE 576  Volvox carteri f. nagariensis
XP_015903396   87 inffnn-egkyqrEKGFRILSLLLHLSQ 113  common house spider
XP_017298764   86 mdlavv-knhpeyDIGWSILSLLSLLAE 112  Asian citrus psyllid
GAX73780       91 cslgl---egtneNLDWSILSLLLGLST 115  Chlamydomonas eustigma
PNW77310       90 kglgi---ksdyhEPESRILHLLVALAG 114  Chlamydomonas reinhardtii
XP_024081715   87 enseyf--kqsnaREKWGIIDLLIKLSY 112  bed bug
RZF37218       88 vnadef-rdhrevDVQWSILQLMACLSD 114  small brown planthopper
TRY61968      223 hqspvfqaghaqhDIRIRLLALLWHLAE 250  Tigriopus californicus
GBM74814       87 laiiek-kndsekEVGFKILAFLLHLWE 113  Araneus ventricosus

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap