6Y4E,6Y4F


Conserved Protein Domain Family
MrpH-like
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cd22566: MrpH-like 
Mannose-resistant Proteus-like fimbriae (MR/P) tip adhesin (MrpH) and similar proteins
This model contains mannose-resistant Proteus-like fimbriae (MR/P) tip adhesin (MrpH) found in Proteus mirabilis, a Gram-negative uropathogen and a major causative agent in catheter-associated urinary tract infections. MrpH is required for MR/P-dependent adherence to surfaces. While MR/P belongs to a well-known class of adhesive fimbriae encoded by the chaperone-usher pathway, MrpH has a markedly different structure compared with other tip-located adhesins in this family. It is a novel class of metal-binding adhesin that requires zinc to mediate biofilm formation.
Links
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Statistics
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PSSM-Id: 412107
Aligned: 41 rows
Threshold Bit Score: 133.568
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Zn binding siteputative ligand
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 3 residue positions
Conserved feature residue pattern:H H HClick to see conserved feature residue pattern help
Evidence:
  • Comment:Zn2+ is coordinated by three conserved histidine residues and a ligand
  • Structure:6Y4E: Proteus mirabilis fimbrial adhesin binds zinc
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                # #                     
6Y4E_A         1 SIFSYITESTgt-----psNATYTYVIERWDPEt----SGILNPCYgwpvCYVTVNHKHtv---nGTGGNPa---FQIAR 65  Proteus mirabil...
TCM69095      22 NIFSTIDEVSvqpgspggtEYLYRFTIHSWETSpgsaaSMTPNPCYgepvCTVAINHREta---aGTAGYTga-nPQCAI 97  Acinetobacter c...
WP_010846299  24 YAGAYVMPISidi---egnQTYTTMEIIAWTEE-----EGILNPCYgwnkCYVGPDVQYqdg-ppGMQGACndtdSCLTN 94  Xenorhabdus nem...
WP_047961490  24 YGGAYVMPVNtvp---kgnQATTTMEIIEWTEE-----EGIPNPCYkwgkCLVGPDVQYkth-qpGMYGSCdiagVCLTD 94  Xenorhabdus kho...
WP_069316943  24 YGGAYVMPVNtinq--sngNILTTMEIIAWTEE-----EGIPNDCYgwskCYVGPDVQYrtggqpGMYGSChdakVCLTD 96  Xenorhabdus hom...
CAE12708      12 NAGAFVMPIGmsed--ndrTPRTTQEIIAWDEN-----DTDPNPCHgsgvCYVGPDVKYryr-lpGMHGSCie-gKHCIE 82  Photorhabdus la...
WP_109394115  22 NIFSYISKVEnisg--gipGLAYIGQIERWTLM-----PGVANPCYnvagCEVYVAHRHysngtaGTYSSRd---PKIAD 91  Proteus
WP_154611493  44 PIRTYIDGQS---------RTHAVQEIISWTED-----SGLLNPCYgqsvCYIGPDVLYsnh-ppGMYGSCid-aRSCLE 107 Providencia stu...
WP_017803072  19 NAGAYVFPLSf-------tNNQVAHKLVSWDEN-----DIDLNPCYgwpsCYIGLDVMYssh-apSMYSSCal-nKHCIR 84  Erwinia toletana
WP_042846034  24 FLYSHIYEISymgs-pnkrTTVYHYSISGWDRLas--dDNTPNPCAswskCYVTVNHVH------DKSKNPgaqiEGIVE 94  Providencia ret...

Feature 1                                        #                                          
6Y4E_A        66 IEkl---rtLAEVRDVVLKn--rSFPIEGQTTHRGpsl--nsnQECVGLFYQpns---sgISPRGKLLPGSLCGA 130 Proteus mirabilis HI...
TCM69095      98 SRgtttartMADLGELYKAs--cPIPVKGYSIHRSvdsrppafPECVGLFYTlrq---slNANEGMMLPGMRCGI 167 Acinetobacter calcoa...
WP_010846299  95 AQly---ptTADVMRAYKRk--fSLPFKARFPIMPn------tSKCVGLFYApyt---spGFGNAQQYRGSTCGK 155 Xenorhabdus nematophila
WP_047961490  95 AQky---ptTADVMRAYKKk--fGIPKRVTFDIMTa------dSECVGLFYApkt---fpGNGNAEKFPNSTCNK 155 Xenorhabdus khoisanae
WP_069316943  97 AHky---rtTAEVMRAYKRq--fGIPKRVTFSILNv------nADCVGLFYAdsl---feRYGNAQQFRGSVCNK 157 Xenorhabdus hominickii
CAE12708      83 ISrl---ktKKEVAEAYKKt--fPLPYRSDFRLISt------dATCIGLFFIrhq--ptlGFSDAELWPGSTCGR 144 Photorhabdus laumond...
WP_109394115  92 ASky---ktMDELREAFLKi--tPLPYTFRVVHSGti----vtSECVGIFYGq------rRSASDPLLPGSICGA 151 Proteus
WP_154611493 108 ISny---rtRAEVANAYKMr--fGIPYQSDFPLQSs------dATCVGLFYIthepvlppAGTDARQWPGSTCGK 171 Providencia stuartii
WP_017803072  85 IEny---rtRKEVMEAWRSa--lGIPFSGSFTVQNa------tARCVGLFYIdqpkqpapENYTAVRFPGSVCSE 148 Erwinia toletana
WP_042846034  95 VTgl---qtLREVQEKVFNtkgyPFTHSGRQGHYGdq----tvDECVTLFLQpvf--sssKFEKGIMMPGALCGI 160 Providencia rettgeri

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