6VVE,6VVC


Conserved Protein Domain Family
Lpg2603_kinase

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cd22555: Lpg2603_kinase 
Legionella pneumophila Dom/Icm type IV secretion system effector Lpg2603 kinase domain
This model contains the kinase domain of the type IV secretion system effector (T4SS) Lpg2603, an atypical kinase from the bacterial pathogen Legionella pneumophila. Lpg2603 is a remote member of the protein kinase superfamily having structural similarity, but notable differences in primary amino acid sequence. Studies show that Lpg2603 is an active protein kinase that requires the eukaryote-specific host signaling molecule inositol hexakisphosphate (IP6) for activity; IP6 binding rearranges the active site to allow for ATP binding and catalysis. The C-terminal domain of Lpg2603 is a PI4P-binding domain.
Statistics
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PSSM-Id: 412101
Aligned: 34 rows
Threshold Bit Score: 390.925
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindinginositol
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:6VVE: Legionella pneumophila Dot/Icm T4SS effector kinase binds Mn-ADP; contacts at 4.0A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
6VVE_A         3 PKINKIVNGTDLTPHYls---------epNKEFKIYRYNNEVYAVRFENDe----pXDYVLXWKSHKsehtqnsexiknt 69  Legionella pneu...
OJW11323       2 PELHEIIDGDDITAHYldeditrdyqermNETFKIFRYNHEVYAVRYDETd----pIDSISMWRSHKgenis-------- 69  Legionella sp. ...
WP_058457739  19 PSIEEIMGGDDITKHYld---------eeNKQYRIYRYNKEVYAVRMEEP------RDFSHMWSSHKgehis-------- 75  Fluoribacter bo...
WP_010653557   9 PSLSEIIRGDEITSHYlgd--------spENKFKIFRYDQEVYAVRYDVNqk---pDDYVSMWRSHKgepkee------- 70  Fluoribacter du...
WP_058451434   2 PSLSEIIGGTDITSHYld---------inQQEFKIIRYENIVYAIRYAQTssqwqaQDFVRMWVSQRkkvktasql--sd 70  Legionella mace...
WP_058525766   3 LSVKEIISGVDITSHYlg---------seSQPFKIFRHNKNVYAVRYNETe----aVDFVHLWGSHKgemqs-------- 61  Legionella erythra
WP_028378767   3 ISINDVIKSADITTHYlg---------daNKEFKIFRHNKDVYAVRYDGAv----pVDFLSLWTSNKgegkt-------- 61  Legionella
WP_058480015   2 PSIEEIMSGKDISKHYlg---------ekSDKFKIFRFKNGVYAVRFNEDqs--kpPDFIQMWVSHKgegtm-------- 62  Legionella walt...
WP_058500998   2 PLISDILSGADITEHYld---------veNEQFKIYRYNKNVYAVRYDENts--qpVDFVHMWHSHKggpkd-------- 62  Legionella isra...
WP_108293987   4 SAKNITSYGVDVTPHYlg---------seNQSFKIFRYEKAVYAVRYDGEd----aIDFVHLWGSHKgemqs-------- 62  Legionella taur...
Feature 1              ####### #       # #                                    #                 #
6VVE_A        70 eedykeLGKGEQGTVYEKTEDKAXKVSRgr-hpREFYEEINLHIIEQQFFLKYHGiq-eHFVLGLWNIKNe--eNVYFYX 145 Legionella pneu...
OJW11323      70 -tpkdkIGQGEEGTVYGKTPDKAMKVSKgggrtQRHATETNLEILRQQFVLNEKDie-qHFVLGLWNIKSp--eNVYFYM 145 Legionella sp. ...
WP_058457739  76 --qrktLGSGQFGTVYQKTNDKAFKEVGrg-edKPRDIKTNLAILDQKFLLKKHNie-eFFVLGLWNIKD----KHVFNM 147 Fluoribacter bo...
WP_010653557  71 nkqyqpLGSGKQGIVYKKTEDKAFKHRRt---tIEGKSQANIEILEQKFLLKEHNie-qFFVLGLWNIKDk--dKVLLFM 144 Fluoribacter du...
WP_058451434  71 nntsnlLGDGTEGEVYKKTEDKAYKIIFskqyqKVDYQEFNVHIMKQKFFLKDNNidtqYFVLGLWNIKNidndWPRFYM 150 Legionella mace...
WP_058525766  62 --kneyLGSGVVGQVFKKTENKAFKEIGdk-kyKGHEIKANLAILEQKFLLQEHGid-qYFVLGLWNIKDk--sNVVFNM 135 Legionella erythra
WP_028378767  62 --kkvyIGSGTFGDVYEKTENKAFKQVGdr-kyKGNEIGTNLDILRQKFLLKDNNid-eYFVLGLWNIKDr--gNVVFNM 135 Legionella
WP_058480015  63 -gepepIGRGLFGVVNKKTTDKAVKTLSgasitPEDGVENNLAILEQQFLLKDHHid-eYFILGLWNIKNk--gNVVFNM 138 Legionella walt...
WP_058500998  63 --ppkyLDQGAFGTVYEKTEDKVFKELEdk-msRGHEKKTNIAILEQKFLLKENNie-eYFILGLWNIKDk--nNVFFNM 136 Legionella isra...
WP_108293987  63 --kneyLGAGVFGQVFKKTEDKAFKELGsr-hyKGTEIKKNLTILEQKFLLKEQGid-eYFVLGLWNIKDk--sHVVFNM 136 Legionella taur...
Feature 1        ###                                                 ## #        ##              
6VVE_A       146 PKINAIPINKk---iDQPKIEEFVLALKELNDaGYWHPDLANNp---yHISPQNLIATEexVKTIDLDgGFRYDKgrv-- 217 Legionella pneu...
OJW11323     146 PKVESANFNRn---nDKPKVEKFILALKEMNDlGYWHRDLANNp---fHYSLQNLFVTTedIKTIDMDaGFAYNDg---- 215 Legionella sp. ...
WP_058457739 148 PKLASAEMKRd---eLKPKFEEFILALKKVNElGYMHPDLANNv---rHNSPQNMLVTAegVRTIDLDsGFMPYVewake 221 Fluoribacter bo...
WP_010653557 145 PKVDTNFPAGykrddFKPLFDEFILALKKLNElGFSHPDLANNl---yHISPQNMLRTTegVRLVDLDyGFVPYKkyaek 221 Fluoribacter du...
WP_058451434 151 PKIKEKNPRElpsdkRFMFLNEFILTLRKLNQfGYAHPDLATYv---gQESFCNMLFTEdgVRLIDIDkGFAKKDyfsf- 226 Legionella mace...
WP_058525766 136 PKLEMKYPSKm---dFQPQYEAFVLGLKKLNErGYCHPDLANDp---wHNSPQNLFFTAegLRTVDLDsGFYPHQ----- 204 Legionella erythra
WP_028378767 136 PKQEKQNVAAe---qMQLMYEDFVIGLKKLNQlGYLHPDLANSh---tHNSPQNLITTEkgIRAIDLDsGFYPYQ----- 204 Legionella
WP_058480015 139 PYVEGNIHAPke--kIRPQFDEFILALKQLNElGYAHPDLANSy---sHSSFQNMIISEsgVRLIDLDkGLWKYN----- 208 Legionella walt...
WP_058500998 137 PSVKETSNNFdd-nkLELMSDEFILALKKLNElGYMHPDLASIkgtrfHWSPQNMLKTVegIRLIDLDrGLDNYR----- 210 Legionella isra...
WP_108293987 137 PKLSLKNPTKd---hLKPLYEQFVLGLKKLNErGYHHPDLANHp---wHTSPQNLLPTAegIKAIDLDeGFCSNE----- 205 Legionella taur...
Feature 1                                                                                        
6VVE_A       218 -------deLSRKSLVYGKDQWLYVYNFIYpptdeedhridWRVPIEKWYENNRDESLSDNPHTLLRFYHEgLISLPkKL 290 Legionella pneu...
OJW11323     216 --------dYDSRRVVFGRDQWIYVYNRIYpphddfdeivhWEHLVDRWYDEHEGQCLSDHPEELLKMYENgELSLPkKI 287 Legionella sp. ...
WP_058457739 222 ptdnpisakFKQQALISGRDQWLYVYNYHYptae---grkvWRKEIEDWYEKNPGKTLSEDPDALYSFYKKgTIALPqSY 298 Fluoribacter bo...
WP_010653557 222 n--ydngtdLKNHTYINGMDQWIFVYNDRRtnlsl--psgmNTDGLENWYEKHSGKALSDHPKALLTLYKNgSITLPkSL 297 Fluoribacter du...
WP_058451434 227 -----fkikGSEDGHINVNDQWLYVYNTHPsnknr-kpyntWTSSVSNWYAHNPNQSLSNNPEALLDMYQNgTISLPeTI 300 Legionella mace...
WP_058525766 205 ---------NNEKMKIYGKDQWLYVYNHRFppent--krnqWRQEIEDWYNKHQGQALSDNPVALFNLHNRgKIALPaDM 273 Legionella erythra
WP_028378767 205 ---------DRANAKVAGKDQWLYVYNYKFppdnk--krnqWRETIDKWYTNNPGKALTDYPEVLLAFHNQgKITLPpRM 273 Legionella
WP_058480015 209 ---------EGQYQAPLARDQWIYVYNHQFsnr-----atpWKIALKHWYDKHPDQPISENPQALLKLYNNgWLSLPtSL 274 Legionella walt...
WP_058500998 211 ---------ENAKFRISGRDQWIYVYNFSQkg--------dWKKVLQHWYEKNEGKSLSDNPKALLSLYKSgSISLPkSV 273 Legionella isra...
WP_108293987 206 ---------SSDEKKVFGRDQWLYVYNYRFppent--vhnqWRQEIENWYNKHKGQALSDHLPALLTLHHQgKIALPaSI 274 Legionella taur...
Feature 1                  
6VVE_A       291 AHDLHETILE 300 Legionella pneumophila
OJW11323     288 VNDLHKDFAS 297 Legionella sp. 39-23
WP_058457739 299 VDELNLRKEE 308 Fluoribacter bozemanae
WP_010653557 298 VYEMHLRNSQ 307 Fluoribacter dumoffii
WP_058451434 301 VNELIDHTQE 310 Legionella maceachernii
WP_058525766 274 VYEMHLKNSD 283 Legionella erythra
WP_028378767 274 VHEMRIQHSD 283 Legionella
WP_058480015 275 VRDMHLKNTE 284 Legionella waltersii
WP_058500998 274 VYEMHLSNSS 283 Legionella israelensis
WP_108293987 275 VNELHLKNSE 284 Legionella taurinensis

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