Conserved Protein Domain Family
SP9_N

?
cd22549: SP9_N 
N-terminal domain of transcription factor Specificity Protein (SP) 9 and similar proteins
Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP9 plays a role in limb outgrowth. It is expressed during embryogenesis in the forming apical ectodermal ridge, restricted regions of the central nervous system, and tail bud. SP8 and SP9 are two closely related transcription factors that mediate FGF10 signaling, which in turn regulates FGF8 expression which is essential for normal limb development. Both SP8 and SP9 have been found in vertebrates, but only SP8 is present in invertebrates. SP9 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP9.
Statistics
?
PSSM-Id: 411695
Aligned: 7 rows
Threshold Bit Score: 380.872
Created: 27-Aug-2020
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
P0CG40        19 MLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAVATggrgs-----gglagGSGAANSAFCLAS 93  human
XP_007888402   1 MLAATCNKIGNTSPLTTLPESGAFGKGGFHPWKRSVSNCSLGSGLSGFGVGSarasgai--ansfsvNGGSGSSAFCLAS 78  elephant shark
XP_006003586  19 MLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSSSSCNLGSSLSGFAVSTsrgst------glatTTGTANSAFCLAS 92  coelacanth
OWK59458      28 MLAATCNKIGNTSPLTTLPESSAFAKGGFHPWKRSTSSCNLGSSLSGFTVATsrgsn------glasGTGTANSAFCLAS 101 Bengalese finch
Q0VA40        19 MLAATCNKIGNTSPLSSLPESSAFAKGGFHPWKRSSSSCSLGSSLGGFAVATsrasg------altgGTATANSAFCLAS 92  tropical clawed...
Q6NW96        19 MLAATCNKIGNTSPLTTLPDSSAFSKGGFHPWKRSSSSCNLGSSLPGFTVATsrsts------glttTTGAGNSAFCLAS 92  zebrafish
BAJ78789       1 MLAATCNKIGSARALSPAADSPAYGKGGFYPWKRPTSSGAGHPGLGTPGQRGdladcasghvaagpsAFSLAASSSSSTA 80  Arctic lamprey
P0CG40        94 TSPTSSAFSSDYggLFSNSaaaaaaaagvspqeagGQSAFISKVHTTaADGL---YPRVGMAHPYESWYKSGFHStlaag 170 human
XP_007888402  79 TSPTSSAFGAEYs-LFSNSvsanv------nsqdtGQSAFISKVHSS-AESLqgmYPRVGMAHPYESWYKSGFHTsisg- 149 elephant shark
XP_006003586  93 TSPTSSAFSSEYgsLFSNTtgvs--------sqesGQSAFISKVHTS-AESL---YPRVGMAHPYESWYKSGFHStisg- 159 coelacanth
OWK59458     102 TSPTSSAFSSDYggLFSNSaaaagv----spqepgGQSAFISKVHSSaAESL---YPRVGMAHPYESWYKSGFHStlsag 174 Bengalese finch
Q0VA40        93 TSPTSSAFSSDYsgLFSSAsgvsp-------qesaGQSAFISKVHAS-AEGL---YPRVGMAHPYESWYKSGFHSdv--- 158 tropical clawed...
Q6NW96        93 TSPTSSAFSAEYssLFSNTtsvs--------sqdsGQSAFISKVHSS-ADTL---YPRVGMAHPYESWYKSGFHStisg- 159 zebrafish
BAJ78789      81 SSSSSPGFPGDYa-LYQAPpvvats----vsspecSQSAFVSKVHTSvQESLqgmYSRVGMAHPYESWFKAGAHAgvsn- 154 Arctic lamprey
P0CG40       171 evtnGAASSWWDVHss-pGSWLEVQNpagglQSSLHSGApq-asLHSQLGTYNPDFSSLTHSAFSSTGlgssaaaASHLL 248 human
XP_007888402 150 -evgSGGSSWWDVHt--nPTWLDVQNpagalQSTLHSGTaq-gpLHSQLGGYNADFSTLSHSAFSSTGig---stASHLL 222 elephant shark
XP_006003586 160 -evaNGASSWWDVHtn-pSSWLEVQNpagglQTSLHSGTpq-asLHSQLSTYNPDFSSLTHSAFSSTGis---ptASHLL 233 coelacanth
OWK59458     175 evanGAASSWWDVHtn-pGSWLEVQNpagglQSSLHSGApq-asLHSQLGTYNPDFSSLTHSAFSSTGlgs--taASHLL 250 Bengalese finch
Q0VA40       159 ---sGGASAWWDVHaagpSTWLEVQNt----QGALHSGAa----AHGQLGAYSPDFSSLTHSAFSSTG-------ASHLL 220 tropical clawed...
Q6NW96       160 -dvaNGASTWWDVHtn-pGSWLEVQNpagtlQSSLHSGTpq--aIHSQLSGYNPDFSSLTHSAFSSTGis---ptASHLL 232 zebrafish
BAJ78789     155 -dvsAGTSAWWDVHa--nSNWLEVQNpagslQGALHSAPlqspaLHSQLGGYSSDFSSLGHSAFSSTGis---asSPHLL 228 Arctic lamprey
P0CG40       249 STSQHLLAQDGFKPVLPSYSDSSAAvaaaaasamisgaaaaaaGGSSARSARRYSGRATCDCPNCQEAERLGPaGASLRR 328 human
XP_007888402 223 STGQHLLAQEGFKSMIPSYNAESASaaisgssi---istpsglGGGSARSSRRYSGRATCDCPNCQEAERLGPaGASLRR 299 elephant shark
XP_006003586 234 STSQHLLTQEGFKPVIPSYTDSTTAnamis--------gaataIGGSARSARRYSGRATCDCPNCQEAERLGPaGASLRR 305 coelacanth
OWK59458     251 STSQHLLTQEGFKPVLPSYTDSSAAvaaasami--sgaaaaaaGGGSARSARRYSGRATCDCPNCQEAERLGPaGASLRR 328 Bengalese finch
Q0VA40       221 PGGQHLLTQDAFKPVLPSYPDSGGPmlsga---------agtgAGGTGRSARRYSGRATCDCPNCQEAERLGPaGASLRR 291 tropical clawed...
Q6NW96       233 STSQHLLTQEGFKTVIPTYTDASATnamis--------gassgIGTSSRSSRRYSGRATCDCPNCQEAERLGPaGASLRR 304 zebrafish
BAJ78789     229 PATQHLLAQDGFKSMLPSYGESPGGgsgglppgp-misgpptlSSSSRALARRFPGRATCDCPNCQEAERLGP-GASLRR 306 Arctic lamprey
P0CG40       329 KGLHS 333 human
XP_007888402 300 KGLHS 304 elephant shark
XP_006003586 306 KGLHS 310 coelacanth
OWK59458     329 KGLHS 333 Bengalese finch
Q0VA40       292 KGLHS 296 tropical clawed frog
Q6NW96       305 KGLHS 309 zebrafish
BAJ78789     307 KGLHN 311 Arctic lamprey
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap