Conserved Protein Domain Family
SP7_N

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cd22542: SP7_N 
N-terminal domain of transcription factor Specificity Protein (SP) 7
Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP7, also called Osterix (Osx) in humans, is highly conserved among bone-forming vertebrates. It plays a major role, along with Runx2 and Dlx5 in driving the differentiation of mesenchymal precursor cells into osteoblasts and eventually osteocytes. SP7 also plays a regulatory role by inhibiting chondrocyte differentiation, maintaining the balance between differentiation of mesenchymal precursor cells into ossified bone or cartilage. Mutations of this gene have been associated with multiple dysfunctional bone phenotypes in vertebrates. SP7 is thought to play a role in diseases such as Osteogenesis imperfecta. SP7 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP7.
Statistics
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PSSM-Id: 411691
Aligned: 7 rows
Threshold Bit Score: 367.301
Created: 23-Jan-2020
Updated: 30-Sep-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8TDD2         2 ASSLLEEEVHYGSSPLAMLTAACSKFGGSSPLRDsTTLGKAG----TKKPYSVGSDLs-----aSKTMGDAYpa-pFTST 71  human
NP_001093375   2 ASPMLEEEARYVSSPLAMLTAACNKFGGSSPIRDsTASAKSG----VKKPYSQVNDFt-----aSKLMGDGYss-tYLGG 71  African clawed ...
XP_007909749   2 AASMLEEDARFGSSPLAMLTATCNKFGGSSPLRDpSTPGKPNvn-pGKNSYSPGSELmaaksrgPEGMADGYagvgVGCG 80  elephant shark
XP_005986366   2 AASMLEEETRYGSSPLAMLTAVYNKFGGSSPIRDsATPGKTGnn-sGKKPCNLNSDLsipksrsSEVMGDSYtt-tFSSG 79  coelacanth
NP_998028      2 AASILEEETRYGSSPLAMLTATCNKFGSTSPVRDsATPGKPGstipIKKAYSMTSELqsakngrNESVADSYtg-sFSSS 80  zebrafish
XP_030054225   2 AASMLEDETRYGSSPLAMLTAACNKFGGSSPIRDsATPGKTGns-sVKKLYSLSSDLsiaksrsSDIMGDSYta-tYPSG 79  Microcaecilia u...
XP_023965670   2 ASPALEEEARYGSSPLAMLTATCNKFGGSSPIRDsATPGKAGnp-lGKKLYQLGAEQsspklrsSEAMGDSYta-aFPSG 79  western painted...
Q8TDD2        72 NGLLSPAGSPpap-tsgYANDYPPFShSFPGPTGTQDPGLLVpkgh-sssDCLPSVYTSLDMTHPYGSWYKaGIHAGISp 149 human
NP_001093375  72 SNIMTSCGTPpas--snYGGEFGSFAhSFPSSSGCQEPKSLSq------aECVPGVYTSLDMGHPYGSWYKtGIHHPSLs 143 African clawed ...
XP_007909749  81 NGLMSTSPNPqss--agYGNDYGPFShSFPPASGAQDPSLLVskgh-ppsDCLHGVYPSLDMGHPYGSWYKtGIHHGISt 157 elephant shark
XP_005986366  80 NGLMSPSGSPqgs--ttYGSDYNPFShSFPTSSGSQDPSLLVskth-psaDCLPSVYTSLDMAHTYGSWYKtGIHPSISt 156 coelacanth
NP_998028     81 GGLLTPTGSPppaptgaYGSEYNPFS-TFQTSSVSQDPSLLGska---taDCLTSVNTYLDMTHPYGSWYK-GIHPGITa 155 zebrafish
XP_030054225  80 SGLMSPSASPqas--ttYSTDYNPFShSFPTSSASQDPSLIVskgh-pstDCLPNVYTSLDMAHPYGSWYKaGIHPGISs 156 Microcaecilia u...
XP_023965670  80 NGLMSPSASPqas--ttYGNDYSPFShSFPASSGSQDPSSLLvskghpsaECLPSVYTSLDMAHPYGSWYKaGIHPGISs 157 western painted...
Q8TDD2       150 g-pgNTPTPWWDMHPGGNWLGGgqgQGDGLQGTLPTGPAQPPLNPQlp-----tYPSDFAPLNpa----------pyPAP 213 human
NP_001093375 144 ssppGSGGSWWDMHPNTNWLGNq-sQPDGLAASMPPVTSPVGMSTQysa---eyTTLTPATYPsvgfpsispssspsPSS 219 African clawed ...
XP_007909749 158 g-stNATTSWWDMHSNSNWLSAp-gQADGLQASFQPVSSQSPINAQls-----gYGSDFGSLNhysp------vglgSPS 224 elephant shark
XP_005986366 157 g-ssNATASWWDMHSNTNWLSAq-tQPDGLQASLQSVPAQTSINPQlsnystefTTLNPTPYPavg---------igSSS 225 coelacanth
NP_998028    156 s-paNATSSWWDVHTNANWLSPgqaQPDSLQAPLQPVAPQASLNPQmpsy-tpdFTPLNPAPYpsv--------glsSSS 225 zebrafish
XP_030054225 157 s-stNATASWWDMHSNTNWLSAq-pQSDGLQPSLQSMPTQNPINAQlpsygsdfTTLNPASYPavg---------itSSS 225 Microcaecilia u...
XP_023965670 158 s-ssNATASWWDVHSNTNWLSAq-pQSDGLQGSLQPVPAQTSLSPQlpsyssdfTTLNPAPYPavg---------itSSS 226 western painted...
Q8TDD2       214 HLLQpGPQHVLPQDVYKPKAVGNSgqlegsggakpprgastGGSGGYGGSGAGRSSCDCPNCQELERLGAAAAGLRKKPI 293 human
NP_001093375 220 HLLS-PSQHTLAPEMYKPKLLAANplles--------pgslKAQRGTSYGNSGRPTCDCPNCQELERLGASAAGLKRKPV 290 African clawed ...
XP_007909749 225 PLLP-SSQHMISQEMFKPKAPANSglmen-------plglkSPSRSSYGGGTGRATCDCPNCQEIERLGVSGVNVRKRAV 296 elephant shark
XP_005986366 226 HLLP-SSQHVLSQDMYKPKPMANNtlmes-------siglkPSRGTSFSGTTGRSSCDCPNCQELERLGASAASLRKKPI 297 coelacanth
NP_998028    226 HLLQ-SSQHMLPQDMYKPKPVPTSgildns-----mglksaRGSGYAAGSTTGRSSCDCPNCQELERLGASAASLRKKPV 299 zebrafish
XP_030054225 226 HLLP-SGQHMLSQDMYKPKPVANNslmdg-------siglkSPRGGSYSSTTGRSSCDCPNCQELERLGTSAASLRKKPI 297 Microcaecilia u...
XP_023965670 227 HLLP-SGQHMLSQEMYKPKPVANNslmeg-------giglkAPRGGTFGSTTGRSTCDCPNCQELERLGASAASLRKKPI 298 western painted...
Q8TDD2       294 HS 295 human
NP_001093375 291 HS 292 African clawed frog
XP_007909749 297 HS 298 elephant shark
XP_005986366 298 HS 299 coelacanth
NP_998028    300 HS 301 zebrafish
XP_030054225 298 HS 299 Microcaecilia unicolor
XP_023965670 299 HS 300 western painted turtle
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