3R9W,1EGA,1WF3,1X18,3IEV


Conserved Protein Domain Family
KH-II_Era

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cd22534: KH-II_Era 
type II K-homology (KH) RNA-binding domain found in GTPase Era and similar proteins
GTPase Era, also called ERA or GTP-binding protein Era, is an essential GTPase that binds both GDP and GTP, with nucleotide exchange occurring in the order of seconds whereas hydrolysis occurs in the order of minutes. It plays a role in numerous processes, including cell cycle regulation, energy metabolism, as a chaperone for 16S rRNA processing, and 30S ribosomal subunit biogenesis. Its presence in the 30S subunit may prevent translation initiation. GTPase Era may also be critical for maintaining cell growth and cell division rates. Members of this family contain only one canonical type II K-homology (KH) domain that has the signature motif GXXG (where X represents any amino acid).
Statistics
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PSSM-Id: 411791
Aligned: 110 rows
Threshold Bit Score: 62.4623
Created: 10-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA bindingGXXG motif
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ###                   #          ####### #########  ##  #          
3R9W_A       201 AEIVREKAMMLTrEEVPTSIAVKINEIKpgdanpnMLVIKGEIIVDRENLKPIIIGKKGQRLKEIGKRARQELELIlg-r 279 Aquifex aeolicus
XP_002899493 436 TEIIREKLFRRFnEELPYSFEQENVGWTkft--dkSIRIDQDIFVPAPRVRKMVVGHNGDTIRSVGMAARDEIEVLlk-r 512 Phytophthora in...
XP_003387981 221 AEVVREKLFKHLhKEIPYSIKQRLVICEer---ddVLYIHKKLTCTKSSQVSIVVGSGGKTVKAIADEAQSHMESLls-r 296 Amphimedon quee...
XP_004343935 236 EEVIREKIFQRTnSDVPYRVWQENLAWYtsk-kdgGYIIHQNILVPNVRIKKILVGEGGRTIKCISMGVQQELEKLck-r 313 Acanthamoeba ca...
XP_004348181 387 CEVIRKHIFNMFvAELPYRVTQETTRWHds---dtTLEVSQKLIVPKASMMKIFIGTNGEKIKKLMALSEEELSRIlg-v 462 Capsaspora owcz...
OEU15599     292 QEIIREKIYRTChREVPHSVQQVNRMFRkip--kkGVIIHQDLVVFTKSHQKLVLGAGGRTLERIRESAQTDLRKMfk-c 368 Fragilariopsis ...
XP_018637773 498 AELIKTYLFCWFnKDVPYRIEQQTIGWTprf--dgSLIIEQELLVKDDKVAKMVCGVRNRLLFQLRRNVSHNLEYNwg-q 574 Toxoplasma gond...
PSC72191     320 LEIVREKLFLRLhQELPYALRLRLVSCLpqp--dnSVRVEIEVVAPNTSAKRIVVGAGGATVAAVADAADAELSAIwr-r 396 Micractinium co...
XP_002774550 301 EQLVRTYIFCWFnKDLPYKVEQQTVGWTprl--dgGLTIEHELKVQDSIVLRMICGTRNRIIRRLRQNVAYKLEQAwgik 378 Perkinsus marin...
XP_001348513 415 EQLINTYIYCWFnKDVPYKVKHHMLSWCvnl--dnSLIIEYQIIVKSEKVAKMICGVHNKLIINMRKNVSYKLTKLwn-k 491 Plasmodium falc...
Feature 1         ### ###  
3R9W_A       280 PVYLELWVKV 289 Aquifex aeolicus
XP_002899493 513 RVHLYLNVRK 522 Phytophthora infestans T30-4
XP_003387981 297 PVQLILSVNH 306 Amphimedon queenslandica
XP_004343935 314 KVHLYLEVKV 323 Acanthamoeba castellanii str. Neff
XP_004348181 463 QVYLHLEVKS 472 Capsaspora owczarzaki ATCC 30864
OEU15599     369 EVSLHLHVKK 378 Fragilariopsis cylindrus CCMP1102
XP_018637773 575 KVILYIHVKA 584 Toxoplasma gondii ME49
PSC72191     397 PVHVALQVKE 406 Micractinium conductrix
XP_002774550 379 PIQLVIWVKA 388 Perkinsus marinus ATCC 50983
XP_001348513 492 NVYVHIHVKS 501 Plasmodium falciparum 3D7

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