Conserved Protein Domain Family
KH-I_PCBP3_rpt3
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cd22522: KH-I_PCBP3_rpt3 
third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 3 (PCBP3) and similar proteins
PCBP3, also called alpha-CP3, or PCBP3-overlapping transcript, or PCBP3-overlapping transcript 1, or heterogeneous nuclear ribonucleoprotein E3, or hnRNP E3, is a single-stranded nucleic acid binding protein that binds preferentially to oligo dC. It can function as a repressor dependent on binding to single-strand and double-stranded poly(C) sequences. PCBP3 contains three K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Links
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Statistics
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PSSM-Id: 411950
Aligned: 6 rows
Threshold Bit Score: 146.797
Created: 14-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNAGXXG motif
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens PCBP2 (2P2R) binds telomeric DNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         ##### ##### ###  #       ## #       #                     
P57721       286 GLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIANATEGSSERQITITGTPANISLAQYLINAR 360 human
XP_007888854 291 GMDANPQASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIANATEGSTERQITITGSPANISLAQYLINAR 365 elephant shark
XP_014348751 259 GLDATTPTSSHELTIPNDLIGCIIGRQGSKINEIRQMSGAQIKIANATEGSTERQVTITGSPANISLAQYLINAS 333 coelacanth
XP_004942582 277 GLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIANATEGSSERQITITGTPANISLAQYLINAS 351 chicken
NP_001315071 259 GLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIANAMEGSSERQITITGTPANISLAQYLINAR 333 zebrafish
OCT61227     277 GMDASPQASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIASAMEGSAERQITITGSPANISLAQYLINAR 351 African clawed frog

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