4OVA,4QW2,4QVZ


Conserved Protein Domain Family
KH_I_FMR1_rpt1

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cd22506: KH_I_FMR1_rpt1 
first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
FMR1, also called FMRP, or synaptic functional regulator FMR1, is a multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. It also plays a role in the alternative splicing of its own mRNA. FMR1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the first one. Members in this subfamily contain a divergent KH domain that lacks the RNA-binding GXXG motif.
Statistics
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PSSM-Id: 411934
Aligned: 8 rows
Threshold Bit Score: 157.819
Created: 13-Aug-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4OVA_A       123 KDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLI 199 human
4QW2_A       124 KDTFHKIKLDVPEDLQQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLI 200 human
4QVZ_A       124 KDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLI 200 human
XP_015140747 123 KDTFHKIKLEVPEDLRQMCAKESAHKDFKKAVGAFSVIYDSENHQLIILSINDVTTKRANMLIDMHFRSLRTKLSLI 199 chicken
P51113       123 KSSFHKVKLDVPEDLRQMCAKDSAHKDFKKAVGAFSVSYDSENYQLVILSVNEVSIKRASMLSDMHFRSLRTKLSLM 199 African clawed frog
XP_005991925 123 KNTFNKIRLDVPEDLRQMCAKESSHKDFKKAIGAFSVTYDSESNQLIILSINDVTAKRATMLSDMHFRSLRTKLSLI 199 coelacanth
NP_694495    123 KNTFLKTRLDVPEDLRQMCAKDSAHKDFKKAIGAFNVTYDSEEKQLVILSVNEVTAKRISMLSDMHFRSLRTKLALI 199 zebrafish
Q06787       123 KDTFHKIKLDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLI 199 human
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