2HH2


Conserved Protein Domain Family
KH-I_FUBP2_rpt4
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cd22488: KH-I_FUBP2_rpt4 
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fourth type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
FUBP2, also called FUSE-binding protein 2, or KH type-splicing regulatory protein (KSRP), or p75, is a single-strand nucleic acid binding protein implicated in a variety of cellular processes, including splicing in the nucleus, mRNA decay, maturation of miRNA, and transcriptional control of proto-oncogenes such as c-myc. It regulates the stability and/or translatability of many mRNA species, encoding immune-relevant proteins, either by binding to AU-rich elements (AREs) of mRNA 3'UTR or by facilitating miRNA biogenesis to target mRNA. FUBP2 contains four K-homology (KH) RNA-binding domains. The model corresponds to the fourth one.
Links
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Statistics
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PSSM-Id: 411916
Aligned: 7 rows
Threshold Bit Score: 129.835
Created: 18-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putative DNAGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens FUBP1 (1J4W) binds ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               ## ### ## ##  ##   #    # ## #          #                     
2HH2_A         8 EMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQLPPNGDPNFKLFIIRGSPQQIDHAKQLIEEK 76  human
AAN77160     379 EMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQPPPNGDPNFKMFIIRGNPQQIDHAKQLIEEK 447 African clawed frog
Q92945       426 EMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQLPPNGDPNFKLFIIRGSPQQIDHAKQLIEEK 494 human
XP_014348579 432 EMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQPPPNGDPNFKLFIIRGSPQQIDHAKQLIEEK 500 coelacanth
XP_007905349 416 EMAFSVPSHKCGLVIGRGGENVKAINQQTGAFVELQRQPPPNGDPNFKLFTIRGSPQQIDHAKQLIEEK 484 elephant shark
Q8UVD9       488 EMTFSIPTHKCGLVIGRGGENVKAINQQRGAFVEISRQLPPNGDPNFKLFIIRGSPQQIEHAKQPIEEK 556 chicken
XP_005160236 377 EMTFSIPAHKCGLVIGRGGENVKAINQQTGAFVEISRQPPPNGDPNFKLFTIRGSPQQIDHAKQLIEDK 445 zebrafish

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