Conserved Protein Domain Family
KH-I_FUBP3_rpt3
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cd22486: KH-I_FUBP3_rpt3 
third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
FUBP3, also called FUSE-binding protein 3, or MARTA2, was previously shown to mediate dendritic targeting of MAP2 mRNA in neurons. It may interact with single-stranded DNA from the far-upstream element (FUSE) and activate gene expression. It is required for beta-actin mRNA localization. It also interacts with fibroblast growth factor 9 (FGF9) 3'-UTR UG repeats and positively controls FGF9 expression through increasing translation of FGF9 mRNA. FUBP3 contains four K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Links
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Statistics
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PSSM-Id: 411914
Aligned: 7 rows
Threshold Bit Score: 143.166
Created: 19-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  ###### #####  ##        # ##         #                      
Q96I24       252 GGGSIEVSVPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGIsPERAAQVMGPPDRCQHAAHIISELI 321 human
NP_001090834 253 GGGSVEVSVPRFAVGIIIGRNGEMIKKIQNDAGVRIQFKPDDGIsPERAAQVMGLPDLCQHAAHIINELI 322 tropical clawed frog
NP_001007777 257 LGSSIDVAVPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGIsPDRVAQVMGQPERCQHAVHLINELV 326 zebrafish
NP_001006199 270 GGGSIEVSVPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGIsPERVAQVMGLPDRCQHAAHIISELI 339 chicken
XP_005992186 260 GGSSIEVAVPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGIsPERVAQVMGPPDRCQHATHLINELI 329 coelacanth
OCT65419     253 GGGSVEVSVPRFAVGIIIGRNGEMIKKIQNDAGVRIQFKPDDGLsPERVAQVMGLPDRCQHAAHIINELI 322 African clawed frog
XP_007900972 271 GGNSVDVAVPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGVmPDRIAQVMGPPDRCQHAAHMINELI 340 elephant shark

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