1J4W,6Y2C


Conserved Protein Domain Family
KH-I_FUBP1_rpt3

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cd22484: KH-I_FUBP1_rpt3 
third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
FUBP1, also called FBP, or FUSE-binding protein 1, or DNA helicase V, or DH V, binds RNA and single-stranded DNA (ssDNA) and may act both as activator and repressor of transcription. It regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. FUBP1 contains four K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Statistics
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PSSM-Id: 411912
Aligned: 8 rows
Threshold Bit Score: 131.572
Created: 18-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA bindingGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1J4W: Homo sapiens FUBP1 binds ssDNA; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ###### #####  ##        # ##         #                      
1J4W_A         3 HMIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRAQHAAEIITDLL 70 
6Y2C_A        18 EGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLL 85  Homo sapiens
NP_998309    268 ESLDVPVPRFAVGIVIGRSGEMIKKIQNDTGVRIQFKPDDGSTPERIAQIMGPPDRAQHAADIITDLL 335 zebrafish
XP_007885441 268 EGLDVPVPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQIIGPPDRCQHAAEILTDLL 335 elephant shark
XP_014345677 236 EGIEVPIPRFTVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPDRIAQITGPPDRCQHAAEIIADLL 303 coelacanth
Q96AE4       276 EGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLL 343 human
NP_001090529 264 EGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGSTPERVAQITGPQDRCQHAAEIVNDLL 331 African clawed frog
NP_001006535 257 GFREVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPDRIAQITGPPDRCQHAAEIITDLL 324 chicken

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