Conserved Protein Domain Family
KH-I_FUBP3_rpt2

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cd22483: KH-I_FUBP3_rpt2 
second type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 3 (FUBP3) and similar proteins
FUBP3, also called FUSE-binding protein 3, or MARTA2, was previously shown to mediate dendritic targeting of MAP2 mRNA in neurons. It may interact with single-stranded DNA from the far-upstream element (FUSE) and activate gene expression. It is required for beta-actin mRNA localization. It also interacts with fibroblast growth factor 9 (FGF9) 3'-UTR UG repeats and positively controls FGF9 expression through increasing translation of FGF9 mRNA. FUBP3 contains four K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Statistics
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PSSM-Id: 411911
Aligned: 6 rows
Threshold Bit Score: 156.991
Created: 19-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     # ### #####  ##  ##    ####                                        
Q96I24       159 DSNSTIQEILIPASKVGLVIGRGGETIKQLQERTGVKMVMIQDGPLPTGADKPLRITGDAFKVQQAREMVLEIIREKDQA 238 human
OCT65419     160 DGSTTVQEILIPASKVGLVIGKGGETIKQLQERTGVKMIMIQDGPLPTGADKPLRITGDPFKVQQARDLVLEIIREKDQA 239 African clawed ...
XP_005992186 167 DGGSSIQEVLIPATKVGLVIGKGGETIKQLQERTGVKMIMIQDGPMPTGADKPLRITGDPFKVQQAREMVLEIIREKDQS 246 coelacanth
NP_001006199 177 DGNSTIQEILIPASKVGLVIGKGGETIKQLQERTGVKMIMIQDGPMPTGADKPLRITGDAFKVQQAREMVLEIIREKDQA 256 chicken
NP_001007777 165 DGSSAVQEILIPASKVGLVIGKGGDTIKQLQERTGVKMIMIQDDPMPTGSDKPLRISGDPYKVQQARELVVEIIREKDQG 244 zebrafish
XP_007900972 180 SSNSAIQEIQIPASKVGLVIGKGGETIKQLQERNGVKMIMIQDGPLPTGADKPLRITGESYKVQLAKEMVLEIIRDKDQG 259 elephant shark
Feature 1           
Q96I24       239 DFR 241 human
OCT65419     240 DFR 242 African clawed frog
XP_005992186 247 DFR 249 coelacanth
NP_001006199 257 DFR 259 chicken
NP_001007777 245 DFR 247 zebrafish
XP_007900972 260 DFR 262 elephant shark

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