Conserved Protein Domain Family
KH-I_NYNRIN_like

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cd22477: KH-I_NYNRIN_like 
type I K homology (KH) RNA-binding domain found in the subfamily of NYN domain and retroviral integrase catalytic domain-containing protein (NYNRIN)
The NYNRIN subfamily includes NYNRIN and KH and NYN domain-containing protein (KHNYN). NYNRIN, also known as CGIN1/Cousin of GIN1, may contribute to retroviral resistance in mammals by regulating the ubiquitination of viral proteins. KHNYN acts as a novel cofactor for zinc finger antiviral protein (ZAP) to target CpG-containing retroviral RNA for degradation.
Statistics
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PSSM-Id: 411905
Aligned: 8 rows
Threshold Bit Score: 123.279
Created: 18-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    # ### #####  ##  ##    ####                            
Q9P2P1         75 PELWKEVRYPPILHCAFLGAQGLFLDCLCWSTlAYLVPGpPGSLMVGGLTESFIMTQNWLEELVGR 140  human
O15037         76 PELQDEIHYPPKLHCIFLGAQGFFLDCLAWSTsAHLVPRaPGSLMISGLTEAFVMAQSRVEELAER 141  human
RXM35200       76 DSAKMEVLYPRDLHCVFTGAKQLFLECLIRGSgAFITVGsQGHLLLSGLTEPVVLARSRIMDLVEK 141  sterlet
XP_003198902   81 QEAQKEMQFPEVLHCIFCGAKGLFMDCLIKHTsAHMVVGsPGFLLISGLTEPVVKAFSFIVDLVEK 146  zebrafish
NP_001108289   90 PEVTEDFDYPREMHCIFVGAKGLFLDCLIKETsAYVKPLaPGQIRISGLAEGAVMAQSWLCASVEK 155  African clawed frog
XP_007479947  119 PEVWEEVGYPAALHCVFFGAGGLFLDCLCWGTsAHIVPQaPGSLLLGGLTEAFVMAQSRMEDLLGQ 184  gray short-tailed opossum
GCF56237       77 PELKEEVWYPKDMQCVFLGAQGLFLDCLTHGTsADLTLLrPGTLLASGLAEAFVMAQSRIQDFVEK 142  Paroedura picta
XP_029436066   82 PEMTKHLSYPKDMHCIFMGATGLFLNCLVRGTsASISLVaHGSLQISGLTESVVMAHSRIQDFVER 147  two-lined caecilian

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