Conserved Protein Domain Family
KH-I_PRP5_like
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cd22474: KH-I_PRP5_like 
type I K homology (KH) RNA-binding domain found in fungal pre-mRNA-processing ATP-dependent RNA helicase PRP5 and similar proteins
PRP5 is an ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. It catalyzes an ATP-dependent conformational change of U2 snRNP. PRP5 interacts with the U2 snRNP and HSH155. Members in this subfamily contain a divergent KH domain that lacks the RNA-binding GXXG motif.
Links
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Statistics
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PSSM-Id: 411902
Aligned: 12 rows
Threshold Bit Score: 147.088
Created: 20-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A6ZLH6        749 GSIIFYAKVYINDLPQIVRWEATKNTTLLFIKHeTGCSITNKGKFYPEGKEPkn--------enDEPKLYLLIEGqdEKD 820  Saccharomyces...
XP_018225200  814 DSREFTATIEINDFPQKARWAVTNRTNIARIIDlTGTSITNKGNWYPPGKPVp----------pGETKLYILIEGetQIS 883  Pneumocystis ...
Q7SH33       1089 DAGAFHATLEINDFPQKARWAVTNRTNVAKILEaTGTSITTKGNYYAPGKEPgp---------gQEPKLYILIEGdtEVV 1159 Neurospora cr...
Q9P7C7        910 DGDEYKAKMEINDYPQQARWAVTNNTNIVHVTElTGTSITTKGNFYLPGKNPe----------pGEEKLYLWIEGpsELV 979  Schizosacchar...
Q4PFD9       1050 DATDYHAIVPINDFPQRARWRVTNKETMRHLIEsTGASITNKGVFYKEGTEPqp---------gEPPKLQLLIESntKSM 1120 Ustilago mayd...
Q6CCZ1        880 PTTAYHTTLQINDFPQQARYRASSNTSVSRVIAnTGCSITAKGEYYPPGRIPgp---------kDEPKLFILIEGtsERA 950  Yarrowia lipo...
Q6BML1        801 DKCKFHSRITINDLPQKARWITVNRDSLSKVIEsTGTSITNKGNYYPPNSKIpktikqngkevtPPPKLYLLVEGltEKA 880  Debaryomyces ...
Q754U8        753 GTSTYFAHVQVNDLPQIVRWEATKYTTLSSIKHeTGCSITNKGRYYPSGQGPqg--------psDEPRLYLLVESatDQD 824  Eremothecium ...
Q6CKI1        710 HSTTYFAHININDLPQLARWEATKTETVSNIKQeTGCNFESKGSFYPEGKGPkn--------dtDDPKLYLIVEGaeESD 781  Kluyveromyces...
A5E058        890 DKCKFYCRVTINDLPQKVRWGIVQRESLSKIIEaSKTSITTRGQFYPPQSKQtp--------tnDQPKLYLLIEGltRKA 961  Lodderomyces ...
Q6FML5        716 GTIATVCKFVVNDLPQLVRWEMTKNTSISNMIReTGCSITLRGRYYPPSNVTnd--------nnTEPKLYLLIEAtdDKA 787  [Candida] gla...
P0CQ98        967 DATDWHAIFPINDYPQKARWKATNKEQMTLLQEvSGASITMRGRFYPPGEEPal---------gGEPKLSLLIESndEMR 1037 Cryptococcus ...

A6ZLH6        821 IQLSIELLEQKVKEGVV 837  Saccharomyces cerevisiae YJM789
XP_018225200  884 VDRALYELKRLLTEGTV 900  Pneumocystis carinii B80
Q7SH33       1160 VGNALSELTRLLREGTM 1176 Neurospora crassa OR74A
Q9P7C7        980 VNRAITELRRLLLEGIN 996  Schizosaccharomyces pombe 972h-
Q4PFD9       1121 VEDAVREIQRLLVEATQ 1137 Ustilago maydis 521
Q6CCZ1        951 VKLAHHELSELLVSGLV 967  Yarrowia lipolytica CLIB122
Q6BML1        881 VHDAIILLREKMIEGLE 897  Debaryomyces hansenii CBS767
Q754U8        825 ISLAIDLLESKVRDGVR 841  Eremothecium gossypii ATCC 10895
Q6CKI1        782 VTMALELLNTKVKEGIR 798  Kluyveromyces lactis NRRL Y-1140
A5E058        962 VEEAAVLIRDKMLQGVE 978  Lodderomyces elongisporus NRRL YB-4239
Q6FML5        788 VRHCVDLLKDNARVGFM 804  [Candida] glabrata CBS 138
P0CQ98       1038 VRAAVEEIRRVLVEGSV 1054 Cryptococcus neoformans var. neoformans JEC21
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