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type I K homology (KH) RNA-binding domain found in DEAD box protein 46 (DDX46) and similar proteins DDX46, also called PRP5 homolog, is an ATP-dependent RNA helicase that plays an essential role in splicing, either prior to, or during splicing A complex formation. It inhibits antiviral innate responses by entrapping selected antiviral transcripts in the nucleus. It is also involved in the development of several tumors. Members in this subfamily contain a divergent KH domain that lacks the RNA-binding GXXG motif. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",