4JVH,2BL5


Conserved Protein Domain Family
KH-I_Hqk
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cd22465: KH-I_Hqk 
type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins
Hqk, also called HqkI, is an RNA-binding protein that plays a central role in myelinization. It binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence and regulates target mRNA stability. It acts by regulating pre-mRNA splicing, mRNA export and protein translation. Hqk is a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia.
Links
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Statistics
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PSSM-Id: 411893
Aligned: 14 rows
Threshold Bit Score: 209.794
Created: 20-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
RNA bindingGXXG motif
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:4JVH: Homo sapiens Quaking protein in complex with RNA; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        # ### #####   #        #####   # #             #                
4JVH_A        76 QLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIXVRGKGSXRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA 155 human
2BL5_A         1 QLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA 80  African clawed ...
Q9YH18        81 QLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA 160 chicken
XP_007887170  81 QLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA 160 elephant shark
Q6P0D0        81 HLQEKLFVPVKEYPDYNFVGRILGPRGLTAKQLEAETGCKIMVRGRSSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDT 160 zebrafish
Q32NN2        82 QLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA 161 African clawed ...
NP_001084987  82 QLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDA 161 African clawed ...
Q6P104        81 QLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGKPNWEHLNEDLHVLITVEDS 160 zebrafish
ELU10377      71 QFSEKLYVPVKDYPEFNFVGRILGPRGMTAKQLEQDTGCKIMVRGKGSMRDRKKEEMNRGKPNWEHLNEDLHVLITVEDS 150 Capitella teleta
XP_013091170  72 QLQEKLFVPVKEYPDFNFVGRILGPRGMTAKELEQFTGCKIMVRGKGSMRDKAKEDQNRGKANWEHLNEDLHVLITVEDT 151 Biomphalaria gl...

Feature 1                               
4JVH_A       156 QNRAEIKLKRAVEEVKKLLVPAA 178 human
2BL5_A        81 QNRAELKLKRAVEEVKKLLVPAA 103 African clawed frog
Q9YH18       161 QNRAEIKLKRAVEEVKKLLIPAA 183 chicken
XP_007887170 161 QNRAEIKLKRAVEEVKKLLVPAA 183 elephant shark
Q6P0D0       161 QTRAEIKMRRAVEEVKKLLVPAA 183 zebrafish
Q32NN2       162 QNRAELKLKRAVEEVKKLLVPAA 184 African clawed frog
NP_001084987 162 QNRAEIKLKRAVEEVKKLLVPAA 184 African clawed frog
Q6P104       161 QNRAEIKLKRAVEEVKKLLVPAA 183 zebrafish
ELU10377     151 KNRASVKLERAKEEVKKLLVPAP 173 Capitella teleta
XP_013091170 152 RNRGEIKLQRAKEEVKKLLVPAP 174 Biomphalaria glabrata

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