Conserved Protein Domain Family
KH-I_PEPPER_like_rpt3

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cd22461: KH-I_PEPPER_like_rpt3 
third type I K homology (KH) RNA-binding domain found in Arabidopsis thaliana RNA-binding KH domain-containing protein PEPPER and similar proteins
The family includes a group of plant RNA-binding KH domain-containing proteins, such as PEPPER and flowering locus K homology domain protein (FLK). PEPPER regulates vegetative and gynoecium development. It acts as a positive regulator of the central floral repressor FLOWERING LOCUS C. In concert with HUA2, PEPPER antagonizes FLK by positively regulating FLC probably at transcriptional and post-transcriptional levels, and thus acts as a negative regulator of flowering. FLK, also called flowering locus KH domain protein, regulates positively flowering by repressing FLC expression and post-transcriptional modification. PEPPER and FLK contain three K-homology (KH) RNA-binding domains. The model corresponds to the KH3 domain of PEPPER and FLK.
Statistics
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PSSM-Id: 411889
Aligned: 6 rows
Threshold Bit Score: 106.483
Created: 21-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  # ### #####  ##  ##    ####                                
Q9SZH4       340 QVSQTMQIPFSYAEDIIGVEGANIAYIRRRSGATITIKESp-hPDQITVEIKGttSQVQTAEQLIQEFI 407 thale cress
PNR40670     402 QVTQHMQIPLSYADAIIGSAGANISYMRRTSGATITIQETrsvPGEMTVEIHGsaSQVQTAQQLIQNFM 470 Physcomitrella patens
ABR16694     318 QVSQRMQIPLSYADAVIGTNGANISYCRRNSGAIITIEETrgvPGEMTVEIHGtaSQVQTAQQLIQNFM 386 Sitka spruce
GAQ84200     307 QIVQKMTVPVAYTDAILGPAGSRLSHIRQTSGATVIVTMAd-aNQNLSFEITGsqTQVSTAQRLVESYM 374 Klebsormidium nitens
XP_024519491 299 SVSQQLQVPLLYADAIIGTAGANINYMRRTSGATISIQETpnaPGEMTIEVHGqsTQVQTAQQLLQNFM 367 Selaginella moellendorffii
Q9SR13       457 QVTQQMQIPLSYADAVIGTSGSNISYTRRLSGATVTIQETrgvPGEMTVEVSGtgSQVQTAVQLIQNFM 525 thale cress

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