Conserved Protein Domain Family
KH-I_MER1_like
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cd22458: KH-I_MER1_like 
type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae meiotic recombination 1 protein (MER1) and similar proteins
MER1 is required for chromosome pairing and genetic recombination. It may function to bring the axial elements of the synaptonemal complex corresponding to homologous chromosomes together by initiating recombination. MER1 might be responsible for regulating the MER2 gene and/or gene product.
Links
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Statistics
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PSSM-Id: 411886
Aligned: 6 rows
Threshold Bit Score: 88.6599
Created: 21-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # ### #####  ##  ##    ####                                        
126980        188 VTLEIKLNKTQITFLIGAKGTRIESLREKSGASIKIIPisdkmtahernhpesvQQTILISGDLYSIALAVTSIES 263  Saccharomyces cer...
XP_022540897  457 FVWEKKLPQSLVGRFIGQKGWHIKHLMEESGAMIELIPlks-----------ssDQIILADGTEKQIATAATMITE 521  Mexican tetra
EDO35530      180 EIWEIEFPQILCGRLIGRKGKNVKAISDQSGAKIRLIPqspg--------evstHRIISLSGDSSQIKSALDSIHD 247  starlet sea anemone
XP_028400434  270 VTWELEFPQALCGRLIGKKGKNVQKISQITGTKIRLIPqnen--------tessQRLVALTGSPKQLRLALRALRE 337  Dendronephthya gi...
EED89108      879 VKKTIYVVSALSKMLTGKKGRKKNQLVEKSGASIQITTian-----------nkHVPVHLSGNQTAVAKAISSIEE 943  Thalassiosira pse...
XP_019638283   75 VGMDVSYSQPLHCIWAGAGGAWHRAVENLSGAAVTVTE----------------VGTLHVSGTDLQVMMAISTLEN 134  Belcher's lancelet

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