Conserved Protein Domain Family
KH-I_Rnc1_rpt3

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cd22457: KH-I_Rnc1_rpt3 
third type I K homology (KH) RNA-binding domain found in Schizosaccharomyces pombe RNA-binding protein Rnc1 and similar proteins
Rnc1, also called RNA-binding protein that suppresses calcineurin deletion 1, is an RNA-binding protein that acts as an important regulator of the posttranscriptional expression of the MAPK phosphatase Pmp1 in fission yeast. It binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling. Overexpression of Rnc1 suppresses the Cl(-) sensitivity of calcineurin deletion. The nuclear export of Rnc1 requires mRNA-binding ability and the mRNA export factor Rae1. Rnc1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Statistics
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PSSM-Id: 411885
Aligned: 7 rows
Threshold Bit Score: 101.767
Created: 20-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       # ### #####  ##  ##    ####                              
O74919               323 QNISIPADMVGCIIGRGGSKISEIRRTSGSKISIAKEPhdetGERMFTITGthEENEKALFLLY 386 Schizosaccharomyces pom...
Q5KIG3               277 QNISIPSDMVGCIIGRGGSKITEIRRLSGSRISIAKVPhdetGERMFTIQGtpEATERALMLLY 340 Cryptococcus neoformans
XP_018227601         308 QNISIPSDMVGCIIGRGGSKISEIRRISGSKISIAKAPhdetGERMFTIQGtsSSNEKALYLLF 371 Pneumocystis carinii B80
KAB8343253           268 QNISIPADMVGCIIGRAGSKISEIRRSSGARISIAKAPhddtGERMFTITGsaAANEKALYLLY 331 Carpinus fangiana
ODQ64964             206 DKFSISVDMVGCLIGKGGAKIQHIRRVSGAKISISKQPdeetGERTFTITGtpEANDRAMKMVH 269 Nadsonia fulvescens var...
KNE57509             173 RTFYCPPNKVGAMIGKGGTKINRVRMQSGCKIQVEDERga-rGDVPFTVTGptLDVDRAMRLLE 235 Allomyces macrogynus AT...
LoveMIT:GQ68_02158T0 304 ETVYFPGELVGAIIGKRGVRIQEIRKLSGCAISIDSANtt-gGERRFVLTGpvRNVDRALAMLT 366 Komagataella phaffii GS115

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