Conserved Protein Domain Family
KH-I_Mextli_like
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cd22454: KH-I_Mextli_like 
type I K homology (KH) RNA-binding domain found in Drosophila melanogaster eukaryotic translation initiation factor 4E-binding protein Mextli and similar proteins
Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster.
Links
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Statistics
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PSSM-Id: 411882
Aligned: 11 rows
Threshold Bit Score: 79.2815
Created: 19-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    # ### #####  ##  ##    ####                                     
Q9VR35       225 KTYCKDEVVIRNADSGKVMGIKGRRVHMIEELSETIISFQRvnp----gakERLVQITGpaeDKINYAKQLMEDTI 296 fruit fly
Q9XW13       240 TLQLRHEMIIRNSDSGKIMGVKGRRVAAVEQLTNTVISFQKvds----kskERTLTITAstmEDIERAKDMIIDTI 311 Caenorhabditis elegans
XP_029834460 209 RNFLKDEIVIRNSDSGKVMGIKGRRVHMIEELSDTVISFQRvnp----gvrDRLVQITGaneDNILRAKDLIEDTI 280 black-legged tick
EFX67467     197 KNSIKDEVVIRNADSGKVMGIKGRRVHLIEEISDTVISFQRvnp----gasERLVQITGaapDNIERARQLIEQTI 268 common water flea
XP_014528800 104 EGEVMEQVIIQSANAGKLIGKGGKTIEQLKEQTETIIRLSSdnemp-edkrNRSVYIIGk-pEKVAEAKKRVIELT 177 Blastocystis sp. su...
EEH54638      86 RVETREAVLVPARLVGAIVGVGGHGARAISGLTATTLTFERddgivnagssTREVVIEGv-pDAVAAAKEMLLRRV 160 Micromonas pusilla ...
XP_002504506 454 GAQHALEVHVEREHIGKVMGYGGMTIKRAQADTQCVMKWDKe---------NQRIQLWGs-pDIVEAGRRRIEDLV 519 Micromonas commoda
XP_009494120 460 PGNETVQFHIPANSAGTVIGRNGDIIRWLQASTNTTVRVEPvdg-----hnNRNVIISGt-pDRIANCRAIINARI 529 Fonticula alba
XP_013239287 421 IGKITISLVMPDEVVGMVIGKKGEYFKWMMAETRCRITVDPpvsd---grpNREITITGp-pEGVAYAQALIHDKV 492 Mitosporidium daphniae
XP_013239287 214 ALKTTIEFVVPGFKVGLIIGKNGETLKRLERMSDCKITFSPltaanpadmpERKVFVTGl-pDDVGHCKRLVLEKI 288 Mitosporidium daphniae
RWS28731      44 TRQSTIKVKVPKDSIGTVIGRGGENIKRIQNETRCRCHFEDfpd----eegNRNVVIRGt-pENILEGKRAIEDII 114 Leptotrombidium del...

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