Conserved Protein Domain Family
KH-I_ScSCP160_rpt4

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cd22449: KH-I_ScSCP160_rpt4 
fourth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
SCP160, also called protein HX, is a new yeast protein associated with the nuclear membrane and the endoplasmic reticulum. It is involved in the control of mitotic chromosome transmission. It is required during cell division for faithful partitioning of the ER-nuclear envelope membranes which enclose the duplicated chromosomes in yeast. SCP160 contains seven K-homology (KH) RNA-binding domains. The model corresponds to the fourth one.
Statistics
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PSSM-Id: 411877
Aligned: 14 rows
Threshold Bit Score: 77.3094
Created: 19-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     # ### #####  ##  ##    ####                                       
1173344       780 ENGHKMVINVPAEHVPRIIGKNGDNINDIRAEYGVEMDFLQkstdpkaqetgeVELEITGSRQNIKDAAKRVESIVAE 857  Saccharomyces c...
XP_004180547  872 QNNEKIKVQIPFKLVSKIIGKGGEIINGIRIDYNVEINSLEttkgkkvekkgyVDFEIIGSKNNIQEAKKKLDSIINE 949  Tetrapisispora ...
ODV86533     2419 ENGFKETIQVPLDILPRIIGKNGENIKDISGETGIEMNHNRkdqvke-keqgyVEFDLTGSKKGIQDAKAKINYMIDR 2495 [Candida] arabi...
EDQ88068      436 LPVFHVQMDVPKAAVSAIIGRQGGNIKDIQRTYDVKMEVDDae--------rvGSVVLDGTFASVQAALTRVRMLVDE 505  Monosiga brevic...
O59810        739 LHSHVEEFDFPAQYSKNVIGKNGSNVSSLREDLGVQINVEE------------GHIRIQGIKKNVEETAARIKSQIEA 804  Schizosaccharom...
XP_011394885  701 ERGFTLEFEFPQKFANHLIGKGGSNIRELREKFDVDIQVQD------------GKVELKGPKAKAEAAKTHILALGRQ 766  Neurospora cras...
CDO51805      671 LSSYTTDFQFPAEHVNKLIGKGGANLTKIREEFGVKIDVDEk-----------GNGVVKGIKKNADEAKVRILNLGRR 737  Geotrichum cand...
OBA25973      787 ADITTLKVEVPFKVRGSVIGAKGLNINKLIEKYNVTIDFDDq----------dINCSIRGNTKNVEKCVSELTKFVDF 854  Hanseniaspora v...
ODV91091      682 RNSYKVALDLEPGFMMSLIGRQGSNIIKLRTDFDCSIEAES------------GAVSIKGVKSNVEAARDEIMKQYKE 747  Tortispora case...
XP_023880516  697 ERGFTLSFDFPQKYASHLIGRKGENINRLRDEFDVDIQLNE------------GKCEIKGPEAKANACKKHILEMAKK 762  Quercus suber

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