Conserved Protein Domain Family
KH-I_ScSCP160_rpt3
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cd22448: KH-I_ScSCP160_rpt3 
third type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
SCP160, also called protein HX, is a new yeast protein associated with the nuclear membrane and the endoplasmic reticulum. It is involved in the control of mitotic chromosome transmission. It is required during cell division for faithful partitioning of the ER-nuclear envelope membranes which enclose the duplicated chromosomes in yeast. SCP160 contains seven K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Links
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Statistics
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PSSM-Id: 411876
Aligned: 7 rows
Threshold Bit Score: 111.849
Created: 19-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    # ### #####  ##  ##    ####                                          
1173344       711 DIITKELIVPvKFHGSLIGPHGTYRNRLQEKYNVFINFPRDn------------------------EIVTIRGpSRGVNK 766  Saccharomyces...
XP_018227377  753 EQTVLHLSIPvKHHGSLIGQGGKFVKRLEEKYQVKINFPREnlenkdtd----------tkkseakDEVTIRGeKNGIAL 822  Pneumocystis ...
XP_011394885  769 DEATHILKIDpQFHRALIGAQGAQINRLQTRYKVLIFFPRTqkasnddesvaeasdagkprrqqaaDEVIVRGpKRGADE 848  Neurospora cr...
BAK07291      799 DEATHVIKIKpQFHKALIGAKGSTVNRLQDRYNVRINFPREdddaaegen--------srkstqapDEVIIKGpKRGADE 870  domesticated ...
RPD74322      733 DETSEVLKIPhQYHSSLIGQSGKYVIRLEDKYGVKITFPREssgdgegr----------treplkaDEVLVKGgRKGVAG 802  Lentinus tigr...
CCA66406      706 DETTEILKVPrQYHSAIIGQQGKYIQRLQDKYGVKINMSKDsst--------------------spDEIQIRGgKKGVSQ 765  Serendipita i...
O59810        807 DDTILRVNIPnDFHRQLIGSNGKYVRRLEEKFSVRVRFPREddssnstgn--------elmkptspDEVVIRGgKKSVAA 878  Schizosacchar...

Feature 1                    
1173344       767 AHEELKALLDF 777  Saccharomyces cerevisiae S288C
XP_018227377  823 AKLELMDLLDY 833  Pneumocystis carinii B80
XP_011394885  849 ARDELLSLLQY 859  Neurospora crassa OR74A
BAK07291      871 AREELLNLLQY 881  domesticated barley
RPD74322      803 AKQELLDAVEF 813  Lentinus tigrinus ALCF2SS1-7
CCA66406      766 AKNEINELVEY 776  Serendipita indica DSM 11827
O59810        879 AKQELLELYEY 889  Schizosaccharomyces pombe 972h-

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