Conserved Protein Domain Family
KH-I_ScSCP160_rpt2

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cd22447: KH-I_ScSCP160_rpt2 
second type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins
SCP160, also called protein HX, is a new yeast protein associated with the nuclear membrane and the endoplasmic reticulum. It is involved in the control of mitotic chromosome transmission. It is required during cell division for faithful partitioning of the ER-nuclear envelope membranes which enclose the duplicated chromosomes in yeast. SCP160 contains seven K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Statistics
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PSSM-Id: 411875
Aligned: 8 rows
Threshold Bit Score: 103.651
Created: 19-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     # ### #####  ##  ##    ####                                         
1173344       632 SSKSKMTVNIPANSVARLIGNKGSNLQQIREKFACQIDIPNEENnnas--------------------kdkTVEVTLTGl 691  Saccharomyces...
Q75FA8        627 SKKSKLTVSVPANTVSRLIGPKGTNLAQIRQKFDVQIDVPSESNd-------------------------tNTEITLTGl 681  Eremothecium ...
KIJ18943      164 SPVVTLTLPAPASTIAAIIGPKGATLKQIRDQTGVRVDIPPKESatpdghvngspngtatpaaaaedeeepTVPVTITGp 243  Paxillus invo...
XP_023905054  303 CSRQNLTVPIPASVRGKIVGKQGANILAITKKTGARINIARQDAtetfad----------------ddedrLVDVTIEGd 366  Quercus suber
GAA94638      233 SRKISISLPIPSSTRSVIIGAKGRTLKAICEETGAQIQIPPRDDaaeqsv---------------epdadpLVDITISGd 297  Mixia osmunda...
RKP27894      226 SPRGQLTLSIPSGTRRFVIGTGGQTLREIERTTGTKIQFPPRDAdaaaea----------------eddaaMVSVTIAGd 289  Syncephalis p...
CAB91673      205 GTKQNITVQIPSSARAHIIGKGGSTIKAIQEKTGARIQLPKADEsqppad----------------edddtMINVHIEGn 268  Neurospora cr...
AYO44459      139 AERVTLTMLIPASLRAFVIGAGGKNIRSITDDTGVRIHIPPRSEeqtpatde-----------pgdlllgeQIEITIEGd 207  Malassezia re...
Feature 1                         
1173344       692 EYNLTHAKKYLAAEAK 707  Saccharomyces cerevisiae S288C
Q75FA8        682 EYNLQHAKTHIASEAK 697  Eremothecium gossypii
KIJ18943      244 QPLAYEAQSMVNEIIS 259  Paxillus involutus ATCC 200175
XP_023905054  367 PFAVQLAKQEIEKVIN 382  Quercus suber
GAA94638      298 ATAVQAAKARVEAIVG 313  Mixia osmundae IAM 14324
RKP27894      290 IAGVKTARERIEQIIS 305  Syncephalis pseudoplumigaleata
CAB91673      269 AFSAAAAQQEIDRIAG 284  Neurospora crassa
AYO44459      208 SFNAQDAQARIQEIVA 223  Malassezia restricta CBS 7877

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