Conserved Protein Domain Family

cd22445: KH-I_Rrp4_Rrp40 
type I K homology (KH) RNA-binding domain found in exosome complex components Rrp4, Rrp40 and similar proteins
The family includes two ribosomal RNA-processing proteins, Rrp4 and Rrp40. They are non-catalytic components of the RNA exosome complex which has 3'-->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. Eukaryotic Rrp4 and Rrp40 contain a divergent KH domain that lacks the RNA-binding GXXG motif.
PSSM-Id: 411873
Aligned: 3 rows
Threshold Bit Score: 102.337
Created: 26-Apr-2019
Updated: 25-Oct-2021
Aligned Rows:
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
  • Structure:2BA0: Archaeoglobus fulgidus Rrp4 is a component of Exosome core; contacts at 4A
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1      ## #                                                                       #  #
6D6Q_H    172 GVLVQVSpslvkrqkt------hfhdlpcgASVILGnNGFIWIYPtpehkeeeaggfianlepvsladrEVISRLRNCII 245 human
2NN6_G    211 GLLFKVTlglirkllapdceiiqevgklypLEIVFGmNGRIWVKAkt---------------------iQQTLILANILE 269 human
2BA0_A    137 GRIVAINparvprvigkkgsmikllkseldVQIVVGqNGLIWVNGd----------------------rRKVSIAEEAIY 194 Archaeoglobus fulg...
Feature 1                         
6D6Q_H    246 Slvtq-rmmlYDTSILYCYE 264 human
2NN6_G    270 Acehm--tsdQRKQIFSRLA 287 human
2BA0_A    195 LieqeahtegLTDRVAEFIK 214 Archaeoglobus fulgidus

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