3V69


Conserved Protein Domain Family
KH-I_KHDC1_like

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cd22440: KH-I_KHDC1_like 
Click on image for an interactive view with Cn3D
type I K homology (KH) RNA-binding domain found in KHDC1-like family
The KHDC1-like family corresponds to a group of structurally related proteins characterized by an atypical RNA-binding KH domain. They are unique to eutherian mammals and specifically expressed in oocytes and/or embryonic stem cells. Family members include KH homology domain-containing protein 1 (KHDC1), KHDC1-like protein (KHDC1L), KHDC3-like protein (KHDC3L, also called ES cell-associated transcript 1 protein or ECAT1), developmental pluripotency-associated 5 protein (DPPA5, also called embryonal stem cell-specific gene 1 protein or ESG-1), Oocyte-expressed protein (OOEP, also called KH homology domain-containing protein 2 or KHDC2, or Oocyte- and embryo-specific protein 19 or OEP19). KHDC3L is essential for human oocyte maturation and pre-implantation development of the resulting embryos. DPPA5 is involved in the maintenance of embryonic stem (ES) cell pluripotency. OOEP plays an essential role for zygotes to progress beyond the first embryonic cell divisions.
Statistics
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PSSM-Id: 411868
Aligned: 10 rows
Threshold Bit Score: 95.8263
Created: 24-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ### #####  ##  ##    ####                               
3V69_A        54 LEDPKRLYVEpRLLEIMFGKDGEHIPHLESMLHTLIHVNvwgp-errAEIWIFGppPFRRDVDRMLTDL 121 house mouse
A6NGQ2        46 LRDPLVFYLEaWLADELFGPDRAIIPEMEWTSQALLTVDivds-gnlVEITVFGrpRVQNRVKSMLLCL 113 human
Q5JSQ8        20 FHSPMVFHMEeDQEELIFGLDDTYLRCIELHSHTLIQLErcftatgqTRVTVVGppMAKQWLLLMFHCV 88  human
Q587J8        39 LKNPKVVRLEvWLVEKIFGRGGERIPHVQGMSQILIHVNrldp-ngeAEILVFGrpSYQEDTIKMIMNL 106 human
A6NC42        20 LKDPEVFQVQtRLLKAIFGPDGSRIPYIEQVSKAMLELKales-sdlTEVVVYGsyLYKLRTKWMLQSM 87  human
XP_006835849  45 LQNPLVIHVEaSLLESIFGPNMVLLKLFERVNETLLDVKvedp-lgdAEITIIGrpWHRKRAEWLLQAM 112 Cape golden mole
VFV47162      42 FLKPSVLHVEaRRLEKIFGPSRTLLPRFEQEFKVLLRMGepds-egkVEIFILGkrRYRKRAKSLIGIL 109 Spanish lynx
Q4VXA5        93 FHAPMVFHMEeDQEELIFGHGDTYLRCIEVHSHTLIQLEswftatgqTRVTVVGphRARQWLLHMFCCV 161 human
Q9CWU5        38 LEDPKRLYVEpRLLEIMFGKDGEHIPHLESMLHTLIHVNvwgp-errAEIWIFGppPFRRDVDRMLTDL 105 house mouse
EFN83479      54 DQESSVVFIQqKDLGKFIGRGGSQIKALEQETNTKMNVDrnqnphgkSAVTIYGsdTDRQRACDTIKKF 122 Harpegnathos saltator

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