2P2R


Conserved Protein Domain Family
KH-I_PCBP_rpt3

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cd22439: KH-I_PCBP_rpt3 
third type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
The PCBP family, also known as hnRNP E family, comprises four members, PCBP1-4, which are RNA-binding proteins that interact in a sequence-specific manner with single-stranded poly(C) sequences. They are mainly involved in various posttranscriptional regulations, including mRNA stabilization or translational activation/silencing. Besides, PCBPs may share iron chaperone activity. PCBPs contain three K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Statistics
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PSSM-Id: 411867
Aligned: 21 rows
Threshold Bit Score: 94.6043
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
DNA bindingGXXG motif
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  ##### ##### ###  #       ## #       #                     
2P2R_A         4 TTSHELTIPNDLIGCIIGRQGAKINEIRQXSGAQIKIANpvegsTDRQVTITGSAASISLAQYLINVR 71  human
EDV19529     281 RSTQLLKIPHDLIGCIIGRGGVKINEIRQISGANIKIASpngdtTGRQVTISGTPESISAAQYLISQS 348 Trichoplax adhaerens
XP_006821505 180 QQTYEIMIPNDLIGCVIGRGGAKINEIRQISGATIKIANsqegsNDRSVTISGTVEAINLAHFLINSS 247 Saccoglossus kowalevskii
XP_011406106 295 TTVQQMRIPNDLIGCVIGRKGTKIHEIRVNSGALIKIASnegdgSDRLVTISGTPESVGIAQYLINSR 362 Amphimedon queenslandica
XP_030828954 325 ATTQEITIPNHLIGCVIGRGGTKIQEIRQMSGANIKIANsqegsTDRSVTITGSPESVAVAQCLINTS 392 purple sea urchin
EDO42485     246 ITSHTMTILKGAVGSIIGQKGSYITGIRQMSGASIKIGDsengdDKREVLITGTAEAVGLAQFLINAR 313 starlet sea anemone
PAA59904     388 TNTQELVIPNDLIGCIIGRGGTKINEIRQLSGAQIKISNcedgaKERKVTITGTPDTISAAQYLISAR 455 Macrostomum lignano
CAE76284     406 ALTQQIYIPNDMVGAIIGKGGQKINEIRQISGSVIKINEpqdnsNERLVTITGTEECNRMALYLLYQR 473 Neurospora crassa
XP_018224928 321 PITQQIFIPNDMVGAVIGKGGTKINEIRQLSGSHIKINEpadnsAERLVTITGTPECNQMALYMLYSR 388 Pneumocystis carinii B80
XP_012562319 195 RSEQKVRLPSNVIGSLIGKGGCHINEIRQFSGATVHVEEskkdnRMSDVIIAGTPEAVSCATFLINAR 262 Hydra vulgaris

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