2AXY


Conserved Protein Domain Family
KH-I_PCBP_rpt1
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cd22438: KH-I_PCBP_rpt1 
first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
The PCBP family, also known as hnRNP E family, comprises four members, PCBP1-4, which are RNA-binding proteins that interact in a sequence-specific manner with single-stranded poly(C) sequences. They are mainly involved in various posttranscriptional regulations, including mRNA stabilization or translational activation/silencing. Besides, PCBPs may share iron chaperone activity. PCBPs contain three K-homology (KH) RNA-binding domains. The model corresponds to the first one.
Links
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Statistics
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PSSM-Id: 411866
Aligned: 21 rows
Threshold Bit Score: 77.6829
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
DNA bindingGXXG motif
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:2AXY: Homo sapiens PCBP2 binds telomeric DNA; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #       ## #####  #   #       #### #   #                         
2AXY_A         7 IRLLXHG----KEVGSIIGKKGESVKKXREESGARINISEgNCPERIITLAGPTNAIFKAFAXIIDKLEED 73  human
P91632        26 IRLIMQG----KEVGSIIGKKGEIVNRFREESGAKINISDgSCPERIVTVSGTTNAIFSAFTLITKKFEEW 92  fruit fly
EDO42485      29 LKMIMQG----KDIGSIIGKEGSTIKQFRQESNAHINISDgSTPERIVSVTGTKDAVVTAFALIGQKLEDE 95  starlet sea anemone
XP_030828957  23 IRLVMQG----KEVGSIIGKKGDTVKRFREESGARINISDgSCPERIVTITGSPEAINLAFKLITKKFDED 89  purple sea urchin
XP_002738761  21 IRLIMQG----KEVGSIIGKGGETIKKFREQSGARINISDsSCAERIVTVTGSTEAINNAFEMITKKFEED 87  Saccoglossus kowalevskii
EFX86525      20 IRLLMAG----KEVGSIIGKKGEIVKRFREESGARINISDgSCPERIVTITGTTDAIFKAFNLICKKLEEE 86  common water flea
EDV19529      48 DKGLVEQ----KEAGRIIGKGGAKIKSFREQSTARINISDgSLPERIVTVNGPIDAVCKAFKLICQKLDED 114 Trichoplax adhaerens
CDS40250      44 IRCLMSR----REAGCIIGKNGETISFLRKRSGAKIKVSDrGVKERIVSVSGNMSAVIRVIKLFCREFAWM 110 Echinococcus multilocularis
XP_011406106  94 IRMIMNS----KDVGSIIGKAGMTIKSFREKSGAKINISNgTSSERLVTVSGTKAEVCVAFTAISRKIEED 160 Amphimedon queenslandica
XP_017298769  17 MRCLFHSsvnvNEISCLIGPGGCIVRRLRKESGAKISITDgACPDRIVTVSGSVDNVCTAYNFMCRSLEDY 87  Asian citrus psyllid

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