Conserved Protein Domain Family
KH-I_HNRNPK_rpt1
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cd22432: KH-I_HNRNPK_rpt1 
first type I K homology (KH) RNA-binding domain found in heterogeneous nuclear ribonucleoprotein K (hnRNP K) and similar proteins
hnRNP K, also called transformation up-regulated nuclear protein (TUNP), is a pre-mRNA binding protein that binds tenaciously to poly(C) sequences. It may be involved in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. It can also bind poly(C) single-stranded DNA. hnRNP K plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. hnRNP K contains three K-homology (KH) RNA-binding domains. The model corresponds to the first one.
Links
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Statistics
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PSSM-Id: 411860
Aligned: 27 rows
Threshold Bit Score: 66.8204
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # ### #####  ##  ##     ####                            
P61978        42 MVELRILLQSKNAGAVIGKGGKNIKALRTd-YNASVSVPDSs-GPERILSISAdiETIGEILKKII 105 human
PIK56706      63 DITLRFLIQSQNAGGIIGKGGQNIKRLRTe-YNAGVTVPDCf-GPERVLTISGkfGDVMGCLEDMM 126 Japanese sea cucumber
EFX66209      32 DTELRLLVYSKVAGSIIGKGGSNISKLRTe-NHATILLPDCp-GPERILTIQGnlDAVINVLQNVL 95  common water flea
WP_155383874  20 SRLLRVLIPSRAAGPIIGKGGETIKDLRAq-YSVRLHIPDSr-GPERVFNMEGdrPNICGCLRELT 83  Nitriliruptoraceae bacterium ...
CBY17960     133 GVGHRFLIPSKMAGAVIGKGGTTIKSLRSd-FACQLNVPDAq-GPERVLRFVCedSNVSPLIEKVG 196 Oikopleura dioica
AHY82402      22 NLQYRFLIPQPAAGAIISKKGETIKRLRAt-YSCDISVPPSn-GPERLMIINTdiDKLCGVLSEIF 85  Schmidtea mediterranea
XP_030547480 151 TVELRLLVRRREAGALIGKRGSNIKRLREtfRSSIFSIPDTgnGPERVVCIATndKSLDGILTDIT 216 Rhodamnia argentea
OQR75202       4 VWDLRFLIPSQRAGAIIGKSGKQIVELRSs-FNCKLVVPDCegVPERLMLVRVsrNLLPQLLTSIL 68  Tropilaelaps mercedesae
P91277        49 KFEVRLLVSSKSAGAIIGKGGENIKRLRAe-FNAHVQVPDSn-TPERVCTVTAdeKTVLNILKDVL 112 Caenorhabditis elegans
EJW86255      39 KYELRLLVTSRGAGAIIGKKGESVKNIQTe-CDATVSVPDSq-TPERVVQLVAavENVVKCVEMII 102 Wuchereria bancrofti

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