Conserved Protein Domain Family
KH-I_RNaseY

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cd22431: KH-I_RNaseY 
type I K homology (KH) RNA-binding domain found in ribonuclease Y (RNase Y) and similar proteins
RNase Y is an endoribonuclease that initiates mRNA decay. It initiates the decay of all SAM-dependent riboswitches, such as yitJ riboswitch. RNase Y is involved in processing of the gapA operon mRNA and it cleaves between cggR and gapA. It is also the decay-initiating endonuclease for rpsO mRNA. It plays a role in degradation of type I toxin-antitoxin system bsrG/SR4 RNAs and also a minor role in degradation of type I toxin-antitoxin system bsrE/SR5 degradation.
Statistics
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PSSM-Id: 411859
Aligned: 47 rows
Threshold Bit Score: 108.05
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 # ### #####  ##  ##    ####                                        
O31774    208 ETTVSVVNLPNDEMKGRIIGREGRNIRTLETlTGIDLIIDDtPEAVILSGFDPIRRETARIALDKLVqDGRIHPARIEE 286 Bacillus subtilis s...
Q9ZL83    214 ENLTSRIALPCSDYVGRVIGKDGKNIEAFKKiSGVDIEFSEdSSELCLSSFNIYRREVASETIKILIeDGRIQPNRIEE 292 Helicobacter pylori...
RLA74756  164 TNFTTTIKITDDKLKGKIIGKNGKNIKALKDiLHVDILLDNeLDNITISNFNIYRREVAKKTIIALLdDGRINENKIET 242 Epsilonproteobacter...
OFZ19218  210 ERGIGYLNFENDEQKNRVLGKDQENLRQVEKiCGVDLAYDEqNNAVNIYGFDPVRRELGRATVDKMMsEMNINPRRIEQ 288 Bdellovibrionales b...
Q2SRU2    197 QRTTNIVKLPSDDLKGRIIGKDGRNMKAFKQiGGVDIVIDEtPNTVVVSSFNPIRREIATRTLEQLIiDGRIQPVKIEN 275 Mycoplasma capricol...
Q8EVM0    147 SKFSFTIKLENEGMKGKIIGKDGRNKRHFEQtTKTDLIIEPnMPAITISSPNPIRREKAKRTMEKLLeTKNMDIAKISL 225 Mycoplasma penetran...
Q9PR60    156 ERSLFNIDIIDENLKGKIIGRDGRNKAVFENeGGVDLIVDRqQPIVGISTPNPIRREIARIVMQKLIdSKNIDINRIEL 234 Ureaplasma parvum s...
Q03E93    204 AENHRSFIAENAEYLGKLIGNSGQNVRAIEAlTGVDIVIDDqEKEVILNGYDPVRRAVAMETMEMIKtEKRVVPDTIER 282 Pediococcus pentosa...
Q7VIL7    211 ERLVNVINLPNDELKGRIIGKEGRNIKTLETiSGVDVIVDDtPGSIILSSFNLYRRAIATKTIEKLVeDGRIQPSRIEE 289 Helicobacter hepati...
Q9PN86    205 ERLINVINIKNDELKGRIIGKEGRNVKTLEMvLGVDIIIDDtPGAIIVSCFNLYRRAIATKVIELLVeDGRIQPARIEE 283 Campylobacter jejun...

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