1WE8


Conserved Protein Domain Family
KH-I_TDRKH_rpt2

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cd22429: KH-I_TDRKH_rpt2 
Click on image for an interactive view with Cn3D
second type I K homology (KH) RNA-binding domain found in tudor and KH domain-containing protein (TDRKH) and similar proteins
TDRKH, also called tudor domain-containing protein 2 (TDRD2), is a mitochondria-anchored RNA-binding protein that is required for spermatogenesis and involved in piRNA biogenesis. It specifically recruits MIWI, but not MILI, to engage the piRNA pathway. TDRKH contains two K-homology (KH) RNA-binding domains and one tudor domain, which are involved in binding to RNA or single-strand DNA. The model corresponds to the second one.
Statistics
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PSSM-Id: 411857
Aligned: 10 rows
Threshold Bit Score: 129.762
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   # ### #####  ##  ##    ####                                           
1WE8_A         14 PVFEQLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKEsegt-----lllSRLIKISGTQKEVAAAKHLILEKVSEDE 88   house mouse
XP_014341496  130 QILEHFHVPQQSVGRIIGRGGEVIRAICRESGAKVACEKEtgdh----rlalERLITLTGTKKEVEVAKKLILEKVEQER 205  coelacanth
Q9Y2W6        124 PVSEQLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKEsegt-----lllSRLIKISGTQKEVAAAKHLILEKVSEDE 198  human
XP_013419646  125 QLVEEMYVPQKAVGRIIGRRGETVRGISRTSKAKIDVEREssrd-----qseVRLITIKGSLEQIKYAKSLIQEKISEED 199  Lingula anatina
XP_785759     124 IITKTLMLPQQAVGRIIGRQGTNIRMIQNTSMARVKIDRDivdg-----ddtKRLCTIRGSIQQVDTAENMIIDEINEME 198  purple sea ur...
GCF44373       47 QVEEQMHVPQRAVGRIIGRGGETVRSICRTTGAKVNCDRQgdga-----fslTRLITISGTRKEVDAAKELITEKLSEDE 121  Paroedura picta
XP_030043422  125 PVSEELLVPQRAVGRIIGRGGETIRVISKSSGAKVFCSREpddk-----lalTRTITVTGTQKEVEAAKQLIQEKVLEEE 199  Microcaecilia...
XP_002612840   52 ILTEEIHLPQRALGRIIGKNGDTIRQLCRTSHAKIKIDRGgder----spdcVKLATITGTKEQIEHARGLLEEKIAEEE 127  Florida lancelet
NP_001014377  153 VITDVIDVPQTAFGRIIGRGGETLKFINRVSGAKVNCSKDrgrt-----leeNGKITITGTRKEIQSAKEMIMEKVIENE 227  zebrafish
XP_027232151  122 IESTEMFVPQYSVGRIIGRSGESIRSVSRISGAKVDVEREeeqsqlirnqedMRRIVLKGSKEQIDAAKSLILEKVAEEE 201  Penaeus vannamei
Feature 1                
1WE8_A         89 ELRKRIA 95   house mouse
XP_014341496  206 EFRQKII 212  coelacanth
Q9Y2W6        199 ELRKRIA 205  human
XP_013419646  200 RFQAQLA 206  Lingula anatina
XP_785759     199 DYNQRLA 205  purple sea urchin
GCF44373      122 VFHRKLA 128  Paroedura picta
XP_030043422  200 ALKKKVL 206  Microcaecilia unicolor
XP_002612840  128 AFRQRLS 134  Florida lancelet
NP_001014377  228 TVRKRIS 234  zebrafish
XP_027232151  202 EMRQQIQ 208  Penaeus vannamei

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