Conserved Protein Domain Family
KH-I_TDRKH_rpt1

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cd22428: KH-I_TDRKH_rpt1 
first type I K homology (KH) RNA-binding domain found in tudor and KH domain-containing protein (TDRKH) and similar proteins
TDRKH, also called tudor domain-containing protein 2 (TDRD2), is a mitochondria-anchored RNA-binding protein that is required for spermatogenesis and involved in piRNA biogenesis. It specifically recruits MIWI, but not MILI, to engage the piRNA pathway. TDRKH contains two K-homology (KH) RNA-binding domains and one tudor domain, which are involved in binding to RNA or single-strand DNA. The model corresponds to the first one.
Statistics
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PSSM-Id: 411856
Aligned: 10 rows
Threshold Bit Score: 105.109
Created: 19-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      # ### #####  ##  ##    ####                                       
Q9Y2W6         49 GEDDIEIEMRVPqEAVKLIIGRQGANIKQLRKQTGARIDVDTEDvg--------deRVLLISGFPVQVCKAKAAIHQIL 119  human
XP_030043422   49 GEDDIEVEMKVPqEAVKLIIGRQGAIIKQLRKETGARIDVDDSEnar-------gdRVLLISGIPVQVCRAKETIRRIL 120  Microcaecilia ...
XP_014341496   50 GEDEIEVEMKVPrQVVKSIIGRQGAIIKQLRRETGACIDIEAQEsegee---sepdRVLLIRGAPVQVCRAKMAIHQIL 125  coelacanth
TFK06728      143 GEDDIEIEMKVPqEAVKLIIGRQGASIKQLRKETGARIDVEAEDsg--------eeRVLLISGFPVQVCRAKAAIHQIL 213  big-headed turtle
ELU02506       48 RSRQTIIEVKVPrDCVGAVIGSGGCVIKQIQEETGARVNFKDEGsqe------gqeRMVIIRGTLTSAQQAEIMIRKII 120  Capitella teleta
XP_013071001   44 TSRTVVIDVSVPpKAVGAIIGRQGATIKQIQKETGARLHFKEKTqngdnssnnlspRTLSIQGSPECAQQAELMVYQII 122  Biomphalaria g...
XP_013419646   46 TSRQTVIEVKVPrEAVAAVIGRQGAQIKEVQEKSGTRINFKDDVgpte-----naeRIAIVRGSPENAQLAELMIRKLI 119  Lingula anatina
XP_009494120  373 PPGHIRKEMQVPgNVVGLIIGRGGDTIRRMQHDFQCRIHFPTTIdgipq--qgapqRVLLLQGEAPAVARAEDAVNSII 449  Fonticula alba
XP_012558525  287 PDQVGYEEIQVPrEAVGFIIGSKGANINNIQQMTGCRIQFKNEMeg--------efKTATLQGNPQAIVMGREKLLEIL 357  Hydra vulgaris
PAA51699      322 GYGESFEEIKVPrRCVGVVIGKGGEMLRKINQDTGAKVQFKQEGpgdr----dlpeRTLQISGNVHCAQMAVERVHELI 396  Macrostomum li...

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