Conserved Protein Domain Family
KH-I_BICC1_rpt3
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cd22422: KH-I_BICC1_rpt3 
third type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
BICC1, also called Bic-C, is a mammalian homologue of Drosophila Bicaudal-C (dBic-C). BICC1 functions as an RNA-binding protein that represses the translation of selected mRNAs to control development. It regulates gene expression and modulates cell proliferation and apoptosis. BICC1 is a negative regulator of Wnt signaling. Increased levels of BICC1 may be associated with depression. Besides, BICC1 is a genetic determinant of osteoblastogenesis and bone mineral density. BICC1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Links
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Statistics
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PSSM-Id: 411850
Aligned: 20 rows
Threshold Bit Score: 102.03
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   # ### #####  ##  ##    ####                                 
Q9H694        284 PVSTQLDIAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDpsn----pqKKSTVYLQGtiESVCLARQYLM 349  human
XP_006004780  285 PVSTQLDIAPQHHLFMMGRNGSNIKHIMQRTGAQIHFPDpsn----pqKKSTVYLQGtiESVCLARQYLM 350  coelacanth
AAH84957      282 PVSTQLDIAAQHHLFMMGRNGCNIKHIMQRTGAQIHFPDpnn----plKKSTVYLQGtiESVCLARQYLM 347  African clawed frog
XP_007895221  236 PVSTQLDIAPQHHLFMMGRNGSNIKHIMQRTGAQIHFPDpsn----pqKKSTVYLQGtiESVCLARQYLM 301  elephant shark
EDV22128      193 PVSVQLDIAPQHHTFIIGRGGSNIKNIMHRTGSSIHFPDtna---apsKRSTVYITGeiEAVCRAREQLM 259  Trichoplax adhaerens
XP_026694733  416 PVSSQIEVAPQQHLYMLGKDAANVKDIMHKTGAQIRFPDpns----lpKKSTIFITGsiEAVVMSRGRLM 481  vase tunicate
Q24009        324 LVNVQMEISPQHHEIVKGKNNVNLLSIMERTQTKIIFPDlsdmnvkplKKSQVTISGriDDVYLARQQLL 393  fruit fly
XP_027222123   61 PVQMTVEISPQHHSFVLGRNNENLKRIMQRTATKITFPDsndlslpplKKSTITISGaiDNVYLARQNIV 130  Penaeus vannamei
EFX67775      280 QVCMTLEISPQHHAVVQGGNKMNLQHIRTVTGTTIMFPDltdphipplRKNTISIRGslDSVLQARLMLM 349  common water flea
NP_981965     289 MVSTQLDVTSQQHLFLLGQNGANFLTVMHQTHTQIILPDlss----pqHTPSLLIQGtaDGVCLARQQLM 354  zebrafish

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