Conserved Protein Domain Family
KH-I_BICC1_rpt2

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cd22421: KH-I_BICC1_rpt2 
second type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
BICC1, also called Bic-C, is a mammalian homologue of Drosophila Bicaudal-C (dBic-C). BICC1 functions as an RNA-binding protein that represses the translation of selected mRNAs to control development. It regulates gene expression and modulates cell proliferation and apoptosis. BICC1 is a negative regulator of Wnt signaling. Increased levels of BICC1 may be associated with depression. Besides, BICC1 is a genetic determinant of osteoblastogenesis and bone mineral density. BICC1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Statistics
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PSSM-Id: 411849
Aligned: 22 rows
Threshold Bit Score: 112.436
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                    # ### #####  ##  ##    ####                                 
Q9H694        131 NRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRnnqaeKSNQVSIAGq-pAGVESARVRIR 200  human
XP_006824914   62 NRVTLKMDVSYTDHSHVIGKGGNNIKKVMQHTGCHIHFPDSNRgnqaeKSNQVSIAGq-pEGVEHARRKIR 131  Saccoglossus kowalevskii
XP_011665574   35 NRVTLKMDVSYTEHSHVIGKGGAIIKRVMDDTKCHIHFPDSNRgsqqeKSNQVSIAGq-iAGVEQARAKIR 104  purple sea urchin
ELU01260       66 TRVTLKLDVPHTEHSHVIGKGGNNIKRVMQDTGCHIHFPDSNRnnqaeKSNQVSIAGq-pSGVEEARSKIR 135  Capitella teleta
XP_026694733  269 TRVTLKMDVSHTEHSHVIGKGGNNIKRVMEETGCHIHFPDSNRnssaeKSNQVSIAGq-pMGVEVARSKIR 338  vase tunicate
Q24009        171 TRVIMKMDVSYTDHSYIIGRGGNNIKRIMDDTHTHIHFPDSNRsnpteKSNQVSLCGs-lEGVERARALVR 240  fruit fly
XP_003386590  142 NRVTLKINIANSEHSHVIGKEGCNIRKVHNDTQCHIHFPDSNRyaqgeKSDQVSITGs-lPAVETARMSVR 211  Amphimedon queenslandica
EFX67775      126 NRVTLKMEVSYTDHSHIIGRGGNTISRVMEETRCHVHFPDSNRtnqteKSNLVTVAGe-lAGVEKARARVR 195  common water flea
OTF77105       70 DKMTFNIDVPYNDHSYIIGKDGTRIKQLSRMTGCHIHLPDCNKts-nkKSNKLSIAGtdfTAIDKARDQIR 139  Euroglyphus maynei
Q21593        102 ERVSLKMELHHSLHSHIIGKGGRGIQKVMKMTSCHIHFPDSNKysdsnKSDQVSISGt-pVNVFEALKHLR 171  Caenorhabditis elegans

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