6GY4


Conserved Protein Domain Family
KH-I_BICC1_rpt1

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cd22420: KH-I_BICC1_rpt1 
first type I K homology (KH) RNA-binding domain found in protein bicaudal C homolog 1 (BICC1) and similar proteins
BICC1, also called Bic-C, is a mammalian homologue of Drosophila Bicaudal-C (dBic-C). BICC1 functions as an RNA-binding protein that represses the translation of selected mRNAs to control development. It regulates gene expression and modulates cell proliferation and apoptosis. BICC1 is a negative regulator of Wnt signaling. Increased levels of BICC1 may be associated with depression. Besides, BICC1 is a genetic determinant of osteoblastogenesis and bone mineral density. BICC1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the first one.
Statistics
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PSSM-Id: 411848
Aligned: 19 rows
Threshold Bit Score: 126.652
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeGXXG motif
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #        #####             ##  ##     ####                      
6GY4_A         2 MSEERFRVDRKKLEAMLQaa--aeGKGRSGe-----------dFFQKIMEETnTQIAWPSKLKIGAKSKKDPHIKVSGKK 68  
XP_023931361  45 VYEERFRVDRRKLEYMLQta--adGMGEGAe-----------qFFQRVMEETnTEITWPSKLKIGAKSKKDPHIKVAGEP 111  Lingula anatina
NP_981965     50 SVEERFRIDRKKLEIMLYap--teASGLSGe-----------eFFEKVMRETnTQVKWPSKLKIGAKSKKDPHVKVEGKR 116  zebrafish
PVD37416      44 FVEDRFRVDRKKLEQMLQlvp-gdAHEENAe-----------dFFQRVMEETsTQITWPSKLKIGAKSKKDPHIKVVGFP 111  Pomacea canali...
GBM86326      45 LTEERFRIDRKKLEDMLLvqqhgnGKIENAe-----------dFFQKVMQETsTQISWPSKLKIGAKSKKDPHVKIVGKP 113  Araneus ventri...
EFX67775      39 LYEERFRVDRRKLESMLLvp--aeGGSEAAae----------rFFLRVMQETsTVIMWPEKLKVGSKSKRDPHVRVAGEP 106  common water flea
CBY15039      69 WVEERFRVDRRKLEEMILv----gNGYQNGe-----------tFFQGVMDKTsTTVTWPSKLKIGAKSKKDPHVKVIGHV 133  Oikopleura dioica
NP_476865     85 LHTERFKVDRQKLEQLIKae--ssIEGMNGae----------yFFHDIMNTTdTYVSWPCRLKIGAKSKKDPHVRIVGKV 152  fruit fly
XP_003386590  58 NVERRFPVDRRKLERLIVa-----GKDKKRsa---------ddFFNDIMKVTgTVILWPSRLKIGAKSKKDPQVKIAGPL 123  Amphimedon que...
PAA90226      33 RVEERFRVDRRKLESLMLts---aGPTSAQeplklpgvcplerFFNDIELRTgARIAWPSKLKVGAKSKRDPQVKVTGSS 109  Macrostomum li...
Feature 1                      
6GY4_A        69 EDVKEAKEMIMSVL 82  
XP_023931361 112 DDVRNAKDRIMCVL 125  Lingula anatina
NP_981965    117 ANVLEAKRKILELL 130  zebrafish
PVD37416     112 EDVKAARSKIMSIL 125  Pomacea canaliculata
GBM86326     114 EAVQMAKDQVLEVL 127  Araneus ventricosus
EFX67775     107 ESVRAAKERIMAVL 120  common water flea
CBY15039     134 DNVKKAKEMILDKL 147  Oikopleura dioica
NP_476865    153 DQVQRAKERILSSL 166  fruit fly
XP_003386590 124 EGVSKAKDAILEEL 137  Amphimedon queenslandica
PAA90226     110 EAVQLAKAMVLSYC 123  Macrostomum lignano

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