2CTM


Conserved Protein Domain Family
KH-I_Vigilin_rpt15

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cd22418: KH-I_Vigilin_rpt15 
fifteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
Vigilin, also called high density lipoprotein-binding protein, or HDL-binding protein, is a ubiquitous and highly conserved RNA-binding protein that shuttles between nucleus and cytoplasm presumably in contact with RNA molecules. It may be involved in chromosome partitioning at mitosis, facilitating translation and tRNA transport, and control of mRNA metabolism, including estrogen-mediated stabilization of vitellogenin mRNA. Vigilin is up-regulated by cholesterol loading of cells and functions to protect cells from over-accumulation of cholesterol. It may play a role in cell sterol metabolism. Disruption of human vigilin impairs chromosome condensation and segregation. Vigilin has a unique structure of 14-15 consecutively arranged, but non-identical K-homology (KH) domains which apparently mediate RNA-protein binding. The model corresponds to the fifteenth one.
Statistics
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PSSM-Id: 411846
Aligned: 23 rows
Threshold Bit Score: 90.4038
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  # ### #####  ##  ##    ####                                   
2CTM_A         17 VSEDVPLDHRVHARIIGARGKAIRKIMDEFKVDIRFPQsg-apDPNCVTVTGl-pENVEEAIDHILNLEEE 85   human
ELU11178     1127 ITEEVTLDTRVHPRLIGQRGRAIRKVMDDYKVDIKFPRpe-sdNPELVMITGs-eDNVLDCKDHLLNLEEE 1195 Capitella teleta
XP_013393956 1130 ITEEVNLDHRVHSRIIGQKGRQVRKIMDDYKVDIKFPRssdndNPDLVVITGm-eDNVLDAKDYLQNLEEE 1199 Lingula anatina
XP_013097099 1217 YVEEVPIDARVHPRIIGTRGRGINKLMEDFEVEIRFPRpn-daDPNLVTITGa-eDNVLDCKDYLLNMEEE 1285 Biomphalaria glabrata
XP_002734359  481 STVEVKIDQRVHPRLIGNKGHAIRKVMEDYKVDIRFPRgn-dvDPDLVTITGm-eDDVLDAKDHLLNLEEE 549  Saccoglossus kowalevskii
NP_496136    1078 FTQEISLDARYHPRLIGQRGKNLKKVMEDYRVEIRLPRqg-aeDPNLVVVAGkdeNDVYDCIDHLRAEEEE 1147 Caenorhabditis elegans
EDO37476     1018 VSVELTIDPRIHRRLIGAKGRAVRKLMEQYKVDIRFPRq---nANDPVVISGq-eQDVEEAKEQLLLLEEE 1084 starlet sea anemone
Q5TRN4        763 YKEEIHIDERVHRRFIGFRGKRLREIKEQFGVDITFPRme-daDKSLVTLAGt-pDNVESCRDYLLNLEEE 831  Anopheles gambiae str....
NP_725787    1147 HREVIEIDKRIHPHLIGQRRRTIRKIIEDNKVNIKFSAdd--dNPNSIFISGk-iEDVENVKELLFGMAED 1214 fruit fly
XP_030535123  879 VEETIEIASQVHPRLIGSGGRSVKKLMEDYKIGVKFARqg-daNPNSVILSGr-pDNVAAAKKHMLKLADQ 947  Rhodamnia argentea

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