2CTL


Conserved Protein Domain Family
KH-I_Vigilin_rpt14

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cd22417: KH-I_Vigilin_rpt14 
fourteenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
Vigilin, also called high density lipoprotein-binding protein, or HDL-binding protein, is a ubiquitous and highly conserved RNA-binding protein that shuttles between nucleus and cytoplasm presumably in contact with RNA molecules. It may be involved in chromosome partitioning at mitosis, facilitating translation and tRNA transport, and control of mRNA metabolism, including estrogen-mediated stabilization of vitellogenin mRNA. Vigilin is up-regulated by cholesterol loading of cells and functions to protect cells from over-accumulation of cholesterol. It may play a role in cell sterol metabolism. Disruption of human vigilin impairs chromosome condensation and segregation. Vigilin has a unique structure of 14-15 consecutively arranged, but non-identical K-homology (KH) domains which apparently mediate RNA-protein binding. The model corresponds to the fourteenth one.
Statistics
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PSSM-Id: 411845
Aligned: 28 rows
Threshold Bit Score: 82.6396
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                # ### #####  ##  ##    ####                                           
2CTL_A      17 FKLSVTVDP-KYHPKIIGRKGAVITQIRLEHDVNIQFPdkddg---------------nqpqDQITITGYEKNTEAARDA 80   human
NP_995886 1074 FVLQVDVDT-EFHSKLIGRHGAVINKLRADHDVIISLPkrde-----------------pndRIISITGYQANAEAARDA 1135 fruit fly
EFX88840  1010 FAVHVEVPP-EYHSKIIGKKGAVISKLRDDFQVNITMPkped-----------------snpQLITIKGYEDNANLAKEA 1071 common water flea
TKR72895   939 FRLDVIVDP-KYHQLLIGPRGSNINKLRADHDVQVSFPptgsrppradgkphretrdpnagpDVIILTGYEANCESCKKA 1017 Steinernema carp...
VVC39754  1186 YEIQMNIEP-EFHPMIIGKKGETVRNLRNKYSVQVNLPrrge----------------gnneDIVTVVGYQENAEKARDE 1248 Cinara cedri
EDV24343  1013 FQIVVEVDP-CHHSKIIGPKGSTISKIRADHNVQVKVPsdke-----------------sndRKIVITGYENEANAAKLK 1074 Trichoplax adhae...
KRX20552  1257 FALQLPIPC-ALVPKLIGIKGREIQRLRSKYDVMISVPqqrg----------------ddgdTEITITGYEENATNCKKE 1319 Trichinella nelsoni
EDQ87291  1136 YTMTMEVPA-SFHVEIIGRNGANVKKLRAEYDVRVDFPrke-------------------gsDEVTLRGYKEKCEACAAA 1195 Monosiga brevico...
Q17832    1007 WSMSINVPT-DYHQKIIGQRGATITALKEKYGVIINVPred-------------------gnETITIQGYEEKANECAAA 1066 Caenorhabditis e...
EFP84426   870 VTITLPVAAgLDRGALIGKGGIYLTRLQDTHMVHIKMPqsrkedn-----------sangndSDITIRGPRKGVEAVKRE 938  Puccinia gramini...
Feature 1                
2CTL_A      81 ILRIVGELEQ 90   human
NP_995886 1136 ILEIVGDPET 1145 fruit fly
EFX88840  1072 ILKMVQDLDD 1081 common water flea
TKR72895  1018 ILDIVAEQDS 1027 Steinernema carpocapsae
VVC39754  1249 IQEMVDKLKN 1258 Cinara cedri
EDV24343  1075 IEKIVQDLEN 1084 Trichoplax adhaerens
KRX20552  1320 IETMVADYKS 1329 Trichinella nelsoni
EDQ87291  1196 IQAQVDKLNS 1205 Monosiga brevicollis MX1
Q17832    1067 IEEMISELRS 1076 Caenorhabditis elegans
EFP84426   939 LIELMEYERE 948  Puccinia graminis f. sp. tritici CRL 75-36-700-3

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