Conserved Protein Domain Family
KH-I_Vigilin_rpt10

?
cd22413: KH-I_Vigilin_rpt10 
tenth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
Vigilin, also called high density lipoprotein-binding protein, or HDL-binding protein, is a ubiquitous and highly conserved RNA-binding protein that shuttles between nucleus and cytoplasm presumably in contact with RNA molecules. It may be involved in chromosome partitioning at mitosis, facilitating translation and tRNA transport, and control of mRNA metabolism, including estrogen-mediated stabilization of vitellogenin mRNA. Vigilin is up-regulated by cholesterol loading of cells and functions to protect cells from over-accumulation of cholesterol. It may play a role in cell sterol metabolism. Disruption of human vigilin impairs chromosome condensation and segregation. Vigilin has a unique structure of 14-15 consecutively arranged, but non-identical K-homology (KH) domains which apparently mediate RNA-protein binding. The model corresponds to the tenth one.
Statistics
?
PSSM-Id: 411841
Aligned: 24 rows
Threshold Bit Score: 86.9301
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                    # ### #####  ##  ##     ####                                
Q00341        726 KSFTVDIRAKPEYHKFLIGKGGGKIRKVRDST-GARVIFPaae----dkdQDLITIIGKEDAVREAQKELE 791  human
CAB52798      741 ASFTAEVRAKQQHHKFLIGKNGASIRKIRDAT-GARIIFPsne----dtdKEVITIIGKEESVKKAREQLE 806  fruit fly
EEC13290      737 SSFTEEVRAQPKHHRFLIGKNGSNIRKVREKT-GARIIFPsdr----desQDTIVLMGKKESVLEAKKLLE 802  black-legged tick
EDV24343      701 HSFTTEVRAKPEFHRFLIGAGGRKINKLKQNT-STRIIFPtqk----dedKELIVIIGTKENIEKTKAELE 766  Trichoplax adhaerens
XP_019852137  716 ENYTEELTCSHEYHKFLIGKGGSKIRKIRSQF-SARVLFPqkgs---gddSSIVTIIGTKENVTAVKEHLS 782  Amphimedon queenslandica
NP_496136     709 NYVEDTVKAKPEFHRFLIGKGGSKIAKLRDTL-NVRVMFPkeg----daeKETIHLLGKKEDVPKAKAALE 774  Caenorhabditis elegans
EFX88840      687 TGYTETIRSKAEHHRFLIGRNGSNIRKIRELT-GARIVFPsdseanntkeRDIITIVGREDAVKKAREELE 756  common water flea
PAA72925      710 DSQEAVIHAKPEFHPFLIGRQGQNAEQLRKAT-GARLVFPslder-gkegGDIITIIGRKEAVAKAKEMLE 778  Macrostomum lignano
EDQ87291      833 NIKIVEMKVEAKHHRFLIGKGGAFRKQIEADSgLFRLAFPsqrte-skedPNTVTLIGTPAAIEKAKAQIE 902  Monosiga brevicollis MX1
CBY11624      720 QSFTAKIDADPSLHRFLIGKNGSNIKDIRDTT-GCRIAVPgan----edkQDQITILGTKEGVAKAKEILE 785  Oikopleura dioica

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap