Conserved Protein Domain Family
KH-I_Vigilin_rpt4

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cd22408: KH-I_Vigilin_rpt4 
fourth type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
Vigilin, also called high density lipoprotein-binding protein, or HDL-binding protein, is a ubiquitous and highly conserved RNA-binding protein that shuttles between nucleus and cytoplasm presumably in contact with RNA molecules. It may be involved in chromosome partitioning at mitosis, facilitating translation and tRNA transport, and control of mRNA metabolism, including estrogen-mediated stabilization of vitellogenin mRNA. Vigilin is up-regulated by cholesterol loading of cells and functions to protect cells from over-accumulation of cholesterol. It may play a role in cell sterol metabolism. Disruption of human vigilin impairs chromosome condensation and segregation. Vigilin has a unique structure of 14-15 consecutively arranged, but non-identical K-homology (KH) domains which apparently mediate RNA-protein binding. The model corresponds to the fourth one.
Statistics
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PSSM-Id: 411836
Aligned: 45 rows
Threshold Bit Score: 59.4916
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 # ### #####  ##  ##       ####                                        
Q00341        297 TIAVEVKkSQHKYVIGPKGNSLQEILEr---TGVSVEIPPsd------------siSETVILRGEp-EKLGQALTEVY 358  human
ODV91091      344 EAKTSIPrARHRFVLGDKGKNVQDLLEt---TGCYVSFPPls------------ssDNTLVIFGPr-SNLSAALERVL 405  Tortispora case...
PJF19251      279 TVSTQVPkPLHRFLVGPKAETLYALEEe---TGCYISVPPpd------------npSDSITVYGKd-DALLKGVRGIL 340  Paramicrosporid...
RKP03100      462 EMDYVLP-RQRHRLIGPKGDFMQQVLEa---TGCTIFLPPig------------daSENIVIHGPa-PLLPKVYSMIL 522  Caulochytrium p...
XP_002162778 1058 EMVVNVPkAYHSKLIGRKGAMIQKLRDe---YGVNIRVPPasntp------dddeqANQIHLIGYe-DKCIKAKEAIE 1125 Hydra vulgaris
KXN74163     1095 ALRIYVPnSHHRHIIGTGGKVINEIRRa---TGCEIELPQngagrggrrdnglfadGIAVVITGPk-DQCYNTKEKIV 1168 Conidiobolus co...
XP_013761341    3 LLTVYIPkEEHGRIVGPGGSVARDVEAa---TGASLTIPRra------------eaSDAVVISGSe-PAIQDAIDAIV 64   Thecamonas trah...
EFP84426      250 EKVLKIPvSVKPFVIGQRGRVMKEIIEv---TGANISLPPkdgnrp----vnvdspAEETTINGS--DEVEMITITIN 318  Puccinia gramin...
XP_004341066  218 RITVRVPkHQHKLIIGAGGKTIREIIKe---TGAKIKIPPgd------------ddDEEVVIEGSp-EAVDQAAERVT 279  Acanthamoeba ca...
XP_005841534  849 EVVMHVPaQLTGMLIGQSGSTIRILQKeasdIGCHIELKQnkppp-------egngAGNLIIHGShgDDVKRVRLRIS 919  Guillardia thet...

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