2CTE


Conserved Protein Domain Family
KH-I_Vigilin_rpt2

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cd22406: KH-I_Vigilin_rpt2 
second type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
Vigilin, also called high density lipoprotein-binding protein, or HDL-binding protein, is a ubiquitous and highly conserved RNA-binding protein that shuttles between nucleus and cytoplasm presumably in contact with RNA molecules. It may be involved in chromosome partitioning at mitosis, facilitating translation and tRNA transport, and control of mRNA metabolism, including estrogen-mediated stabilization of vitellogenin mRNA. Vigilin is up-regulated by cholesterol loading of cells and functions to protect cells from over-accumulation of cholesterol. It may play a role in cell sterol metabolism. Disruption of human vigilin impairs chromosome condensation and segregation. Vigilin has a unique structure of 14-15 consecutively arranged, but non-identical K-homology (KH) domains which apparently mediate RNA-protein binding. The model corresponds to the second one.
Statistics
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PSSM-Id: 411834
Aligned: 21 rows
Threshold Bit Score: 103.544
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      # ### #####  ##  ##    ####                                   
2CTE_A         13 LQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRpdDPSNQIKITGTKEGIEKARHEVLLISAEQDK 87   human
EEC13290      161 LQTQASGSIQIPKEHHRFILGQKGKNLKELEQTTATKIHVPRtdENSDTITITGSKEGIDLARDHIQKISEEKSK 235  black-legged tick
XP_027228315  158 FQTQARQIIKIPKEHHRFILGKKGKKLQELEINTATKIQVPNaaDNSDEIIVVGTKESTEKAMHEIQLISDEQSK 232  Streptococcus pneu...
ELU11178      148 LQTQAHDQVKIPKEHHRYLLGPKGKKLADLELKTASKISIPRleENSDMVTITGTRDGIERARHEIQLISDEQAK 222  Capitella teleta
XP_013393956  142 LQTQANVTMKIPREHHRFILGKSGKKLQELELNTTTKITIPRpeENSDVIRIVGTKEGIDKARHELQLITDEQAK 216  Lingula anatina
XP_792502     146 LQTQANITVQIPKEHHRFVIGKEGKKLKELEQATMTKITIPNseENSDMIRILGPKEGIDQAKHELQLISDEQAK 220  purple sea urchin
XP_006818023   41 LQTQANVTLSIPKEHHRFILGKHGAKLKDLELNTATKISIPRteDNSDVLRITGTRDGIDKAKHEIQLISEEQSK 115  Saccoglossus kowal...
CAB52798      165 FSTQASRQVTVPREHFRVILGKGGQRLREIERVTATRINIPSqsDESEFITIAGTKEGIAQAEQEIRQLSAEQYK 239  fruit fly
EFX88840      142 FQTQSSSAVEIPKEYHGFILGKGGVKLKELEKQTATKITIPKetESSGRIVVSGPKEGIEKALHEIQMISDERSK 216  common water flea
XP_019852137  138 LHTKYNVELRVPKQHHGMLLGKQASNIKQLEQSTNTKISVPRqeDSSETVRITGNKEGVEVARQRLMSFTEDLSK 212  Amphimedon queensl...

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