Conserved Protein Domain Family
KH-I_Vigilin_rpt1
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cd22405: KH-I_Vigilin_rpt1 
first type I K homology (KH) RNA-binding domain found in vigilin and similar proteins
Vigilin, also called high density lipoprotein-binding protein, or HDL-binding protein, is a ubiquitous and highly conserved RNA-binding protein that shuttles between nucleus and cytoplasm presumably in contact with RNA molecules. It may be involved in chromosome partitioning at mitosis, facilitating translation and tRNA transport, and control of mRNA metabolism, including estrogen-mediated stabilization of vitellogenin mRNA. Vigilin is up-regulated by cholesterol loading of cells and functions to protect cells from over-accumulation of cholesterol. It may play a role in cell sterol metabolism. Disruption of human vigilin impairs chromosome condensation and segregation. Vigilin has a unique structure of 14-15 consecutively arranged, but non-identical K-homology (KH) domains which apparently mediate RNA-protein binding. The model corresponds to the first one.
Links
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Statistics
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PSSM-Id: 411833
Aligned: 20 rows
Threshold Bit Score: 95.0556
Created: 14-Aug-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    # ###   ####  #    ##  ##       ####                           
Q00341         77 TQVFHVPLEERKYKDMn--QFGE--GEQ--AKICLEIMQRTGAHLELSlaKDQGLSIMVSGKlDAVMKARKDIV 144  human
CAB52798       95 THIVHVPCKERKSTESe--KFGE--GES--KRICQQITKETGAQIEIVsgKNQSLTFLIKGKqSELLDARRKIL 162  fruit fly
EEC13290       88 TQIFHVPSEERRFRETssqRFGDl-GEQ--AKICADIMRDTQTTIEVSssRDLSLTVLVTGReRNVALARAHVM 158  black-legged tick
EDO37476       56 TQVFRVPLEERRYKLFheaTFGD--ERQ--HSICRDIMAKTGASIEVSlgKDLSLTIMVTGKpDTVAKARRLVL 125  starlet sea anemone
XP_027228315   87 TQVFRVPFEERAKIDGn-nQFGE--SAS--TRICSDITGRTGAHIEISsaKDQSLTFLVTGKsDAVMKARRLVL 155  Penaeus vannamei
XP_026691860   63 TQIFHIPMEERAFKQS---EFGQsqKDQ--SKVCIDIMRITDTMIEMStcRDGSLSLLVSGKaENVLKARREIF 131  vase tunicate
EFX88840       72 TQVFHIPPEERRVDASn--KFGE--GDL--LKTCADIMQSTGATIETSyaKDQSLTFVVIGKqDSVLEAKREIL 139  common water flea
XP_019852137   65 TQIISVPVEERRYKSSd-pSFGG--GDSqqAAVVRDIMSKTGCTIEMNqaKDMSLSIMITGRpSSVKEAHRLIM 135  Amphimedon queensla...
XP_002113869   51 TQVFHVPMEERKFGRHgeqVLGPe-QQQ--AQVCKEVMQKTNTTIEVSstKDQTLTIMVTGKkDAVAKAKRLIL 121  Trichoplax adhaerens
XP_001747904  188 DQMFRIPYEEQKYKTDh--PFSQ--KDF--NKILKETIQATGAKISASnsRDKTLTLTVTGSrSQVNAAKKTVL 255  Monosiga brevicolli...

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