Conserved Protein Domain Family

cd22404: KH-I_MASK 
type I K homology (KH) RNA-binding domain found in Mask family proteins
The Mask family includes Drosophila melanogaster ankyrin repeat and KH domain-containing protein Mask, and its mammalian homologues Mask1/ANKHD1 and Mask2/ANKRD17. Mask, also called multiple ankyrin repeat single KH domain-containing protein, is a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase signaling. It acts as a mediator of receptor tyrosine kinase (RTK) signaling and may act either downstream of MAPK or transduce signaling through a parallel branch of the RTK pathway. Mask is required for the development and organization of indirect flight muscle sarcomeres by regulating the formation of M line and H zone and the correct assembly of thick and thin filaments in the sarcomere. Mask1/ANKHD1, also called HIV-1 Vpr-binding ankyrin repeat protein, or multiple ankyrin repeats single KH domain, or Hmask, is highly expressed in various cancer tissues and is involved in cancer progression, including proliferation and invasion. Mask2/ANKRD17, also called ankyrin repeat protein 17, or gene trap ankyrin repeat protein (GTAR), or serologically defined breast cancer antigen NY-BR-16, is a ubiquitously expressed ankyrin factor essential for the vascular integrity during embryogenesis. It may be directly involved in the DNA replication process and play pivotal roles in cell cycle and DNA regulation. It is also involved in innate immune defense against bacteria and viruses.
PSSM-Id: 411832
Aligned: 19 rows
Threshold Bit Score: 88.8066
Created: 17-Jul-2020
Updated: 25-Oct-2021
Aligned Rows:
putativeGXXG motif
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1                  # ### #####  ##  ##    ####                                            
O75179       1726 RSKKVSVPSTVISRVIGRGGcNINAIREFTGAHIDIDKQKdk------------------------tGDRIITIRGGTES 1781 human
Q9VCA8       3037 TCKKVQVPVNAISRVIGRGGsNINAIRATTGAHIEVEKQGkn------------------------qSERCITIKGLTDA 3092 fruit fly
PVD39592      981 KSKKVQVPANAISRVIGRGGcNINAIRETSGAHVEVEKPKg-------------------------sGDRFIMIKGSAEA 1035 Pomacea canal...
PIK34607       25 RSKKVTIPPSSISRVIGRNGvNINTIRDVTGAHIDVERQNnk------------------------gGERNINIKGSAEA 80   Japanese sea ...
RMX55152     1500 RSKKMSVSSSVISRVIGRGGcNINAIRETTGAHIDIDTNRqk-----------------------ttGSCIVTIKGPADA 1556 Pocillopora d...
XP_019856737 1706 ITRKITIPGSKYSSVVGRGSnRLILIRQLTGAHIEVEKGSrq------------------------aPLRNVTIKGSQDA 1761 Amphimedon qu...
ACO61952      517 QQREIYVPNVKVGLVIGKGGsHVVYFQHQSGCAIHIARDAgeipggvnyvvppsayadpsddavtadGMRRITLLGGEHQ 596  Micromonas sp...
Q60J38       1865 KAYEFTVPGKIVSRVIGKSGsNINAVREATLAQIEIDKLCgs-----------------------keDDRHITVRGSADV 1921 Caenorhabditi...
CBY14390       26 QLQELRVPNQHMGAIIGKGGkRIGEIRMMSGCNIHVERSDads----------------------kyGMRRLTLKGTKQQ 83   Oikopleura di...
Feature 1                        
O75179       1782 TRQATQLINALIKDP 1796 human
Q8IWZ3       1752 TRYAVQLINALIQDP 1766 human
Q9VCA8       3093 TKQAHMLILALIKDP 3107 fruit fly
PVD39592     1036 TRQAHAMINALVQEP 1050 Pomacea canaliculata
PIK34607       81 TRQAAQLITALIKEP 95   Japanese sea cucumber
RMX55152     1557 TRQAHQLISALVKDP 1571 Pocillopora damicornis
XP_019856737 1762 VKQAIHFISVLQKDP 1776 Amphimedon queenslandica
ACO61952      597 TMMAADMIRRLVESS 611  Micromonas sp. RCC299
Q60J38       1922 VSMAVNIIHLLIYDK 1936 Caenorhabditis briggsae
CBY14390       84 ITMAAYLVNQTISSF 98   Oikopleura dioica

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