6GQE,6QEY


Conserved Protein Domain Family
KH-I_IGF2BP_rpt2
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cd22401: KH-I_IGF2BP_rpt2 
second type I K homology (KH) RNA-binding domain found in the insulin-like growth factor 2 mRNA-binding protein (IGF2BP) family
The IGF2BP family includes three members: IGF2BP1/IMP-1/ CRD-BP/ VICKZ1, IGF2BP2/IMP-2/ VICKZ2, and IGF2BP3/IMP-3/VICKZ3, which are RNA-binding factors that recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). They function by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. IGF2BP proteins contain four K-homology (KH) RNA-binding domains which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. The model corresponds to the second one.
Links
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Statistics
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PSSM-Id: 411829
Aligned: 22 rows
Threshold Bit Score: 103.46
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                   # ### #####  ##  ##     ####                                         
6GQE_A        91 PLKILAHN---NFVGRLIGDDGrNLKKIEQDTd-TKITISplqel-------------tlynPERTITVKGnvETCAKAE 153 human
XP_019857610 281 PLKVLAHN---ELVGRVIGKGGnTLKRIMAESg-TKITISklkdl-------------taynMERTITILGtiDNCKKAE 343 Amphimedon quee...
ELU05631     278 VLKILADN---RYCGRVIGREGrVIKKIREDTq-TKITVSndsdhllelghghglqdvasmfPERVISVRGdiDHMSEAE 353 Capitella teleta
XP_013061632 260 PFRILCPN---SICGRIIGKQGnVIKVFMEKTn-TNIVVSsfdpfpgg------lmdstsnfVDRVITITGstESCSEAE 329 Biomphalaria gl...
XP_002737239 311 PLKLLAHN---SLVGRLIGKGGtTLNKIMEESn-TKVSISnlqel-------------tiynMERTITIKGslNDECKAE 373 Saccoglossus ko...
CBY40123     117 PLKVLAHN---ALIGRLIGRDGrNLKHVQDKTg-TRIAISsmhel-------------spynMDRTISIHGevKGISEAE 179 Oikopleura dioica
PAA88048     274 DLGILAED---RFCGRIIGKDGkNLNTIREKSk-TSIQLSnsptitty------dsssptfsLDRIITVKGslEGMCQAE 343 Macrostomum lig...
XP_002157937 226 QLKLLAHD---LLCGRIIGKGGnNLKQTKQESnvSKLIISnsiyeessq----miptgfvctGERVITIEGslDAICIAE 298 Hydra vulgaris
XP_030547494 101 QLKLLAHN---NLIGRLIGRKGaSIKEIMEQTn-TKINIAtnsl--------------tdstNEHTVTIAGqfAQVRQAE 162 Rhodamnia argentea
XP_009029420  71 EIMACLHKsqiNNNARIIGRDGrGIRKVREDSe-ARISISnvqem-------------aslyPDRVITIRGtlESMSLAE 136 Helobdella robusta

Feature 1                 
6GQE_A       154 EEIMKKIRE 162 human
XP_019857610 344 SLISAKLRA 352 Amphimedon queenslandica
ELU05631     354 GAISTILRE 362 Capitella teleta
XP_013061632 330 EKISEKMRQ 338 Biomphalaria glabrata
XP_002737239 374 EMVSEKLRD 382 Saccoglossus kowalevskii
CBY40123     180 QQITEKLRQ 188 Oikopleura dioica
PAA88048     344 KFLSEKLRQ 352 Macrostomum lignano
XP_002157937 299 SLISKKLRE 307 Hydra vulgaris
XP_030547494 163 NLVSSKMRA 171 Rhodamnia argentea
XP_009029420 137 SAISERLRE 145 Helobdella robusta

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