6GQE,6QEY


Conserved Protein Domain Family
KH-I_IGF2BP_rpt1
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cd22400: KH-I_IGF2BP_rpt1 
first type I K homology (KH) RNA-binding domain found in the insulin-like growth factor 2 mRNA-binding protein (IGF2BP) family
The IGF2BP family includes three members: IGF2BP1/IMP-1/ CRD-BP/ VICKZ1, IGF2BP2/IMP-2/ VICKZ2, and IGF2BP3/IMP-3/VICKZ3, which are RNA-binding factors that recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). They function by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. IGF2BP proteins contain four K-homology (KH) RNA-binding domains which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. The model corresponds to the first one.
Links
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Statistics
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PSSM-Id: 411828
Aligned: 24 rows
Threshold Bit Score: 96.958
Created: 17-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                # ### #####  ##  ##    ####                                  
6GQE_A        10 PLRLLVPTQFVGAIIGKEGATIRNITKQtqSKIDVHRKenag-aaeKSITILStPEGTSAACKSILEIM 77  human
EDV26776     139 PLRILVPTEMVGAIIGREGNTIRSITQQtqARVDVHRReslg-saeKAITILGtPDSCTSAALQIAKIM 206 Trichoplax adhaerens
XP_019857610 188 PLRILVPSEMVGAIIGKDGATIRHITQLtkARVDVHRRenlg-smeKAITIIGgPESCTEACYQIMRIM 255 Amphimedon queenslandica
XP_023931508  53 PLRILVPREMVGAVIGRGGETVRQITQQsrARVDVHRKetvpgsveKAITIYGaPENCTKACKEIMAVV 121 Lingula anatina
ELU05631     193 ALKILVPSDFVGAIIGKGGETIRTITKKcnSRVDVHGKensg-lleKVISIYGnPENCTSACKEILLVM 260 Capitella teleta
XP_013061632 181 PLRIVVASDYVGAIIGKQGQTIRKITSEsrARVDIHRResh--vpdTLVTIKGsPESCSRACKEIMTVV 247 Biomphalaria glabrata
XP_002737239 229 PVRLLVPSSMVGAIIGKKGANIRLITQQtkAKVDILRSkenasaleKAINIYGtPLQCSNTVEQIMETM 297 Saccoglossus kowalevskii
EDO32483      78 SIRMLIPCKMVGAVIGTSGNKIKKITEAtnTSIDIHRKedrr-evdKLVTIRGsPQDCSNANMQIHQLM 145 starlet sea anemone
Q7PZV0        57 PLRVLVQSEMVGAIIGRQGSTIRHITQQsrARVDVHRKdnvg-sveKAITIYGnPENCTMACKKILEVM 124 Anopheles gambiae str. PEST
OAF71255      92 PLRILVPVEFIGAIYGKGGARIKTITQDsgAKISIDSKenif-yskKLVSIYGeCKECESACFQILNAT 159 Intoshia linei

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