4QMF,5JPQ


Conserved Protein Domain Family
KH-I_KRR1_rpt1

?
cd22393: KH-I_KRR1_rpt1 
first type I K homology (KH) RNA-binding domain found in KRR1 small subunit processome component and similar proteins
KRR1, also called HIV-1 Rev-binding protein 2, or KRR-R motif-containing protein 1, or Rev-interacting protein 1, or Rip-1, or ribosomal RNA assembly protein KRR1, is a ribosomal assembly factor required for 40S ribosome biogenesis. It is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. KRR1 contains two K-homology (KH) RNA-binding domains. The model corresponds to the first one. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif and is involved in binding another assembly factor, Kri1.
Statistics
?
PSSM-Id: 411821
Aligned: 54 rows
Threshold Bit Score: 116.485
Created: 23-Apr-2019
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
 
oligomer
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Structure:5JPQ: Chaetomium thermophilum KRR1 is a component of the 90S pre-ribosome; contacts at 4A

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                    # ########                       #######          ###  #                   
4QMF_B                4 FAEESSFMTLFPKYRESYLKTIWNDVTRALDkhNIACVLDLVEGSMTVKTTRKTYDPAIILKARDLIKLLARSVPFPQAV 83  Saccharo...
5JPQ_GG              33 FLEESSFMTLFPKYRERYLKDCWPLVTKALEkhGIAATLDIVEGSMTVKTTRKTYDPAAILKARDLIKLLARSVPAPQAL 112 Chaetomi...
EQB61752             15 FNEKSSLIVYYPKYREKYIKQVSQYIKKALEnkKLSCIINYEERSIEISTNKQTRDPFIFIKGCEFIKIICKNIEVEIGM 94  Nosema a...
ELA48248             12 FLAKSRFEIVYAKHLEDSLKESYKSMRTLLRekNIRIKMDRDERLIQVSTTSKTRDPYVILKSKDFVTLICKGVPLEEAQ 91  Vavraia ...
WGS:AFBI:EDEG_01475  17 FTEQSEFTVVFPDWRKQYIKDKQEKIEELLTekKLKLEVNYEDKILKVLTTNKTRDPYIIIKGRDFINLISRGAVFEEAT 96  Edhazard...
KCZ81349             20 FLEKSEFTILYPEWRNEYIVKNKEPMMELLKyqKIDCIVKLKERSITISTNENTRDPYVILKANDFVRLVCRGVPLKEAN 99  Anncalii...
ELP89164             21 LVEESQFSVAFPKFREAYIKSILPALVAKLEefKLKIDVDYLQGSFVIKTTRKTFDPFIIIKGRDMLKLIGRGADLELAS 100 Entamoeb...
EHY65209             42 FLETSSFEIMFPKHREKYIRDTEEYIRKALAqkTLLLAVDYHELVLKVETTPHTRDPYVVLQGRDMLKLVSRGVPLEKAI 121 Nematoci...
ELA42474             30 FLEVSVFEVLFPKHRAQYLKGVESYAIKACEvkKVHFEVDYDKFTMRVSTTDRTRDPYIIIKAYEMIQLLGRGVTLENAV 109 Vittafor...
XP_654627            22 LLEESSFSILFPKYRESYLKGMWYVINKALDevCLKGELDLVKGIMTVKTTRKTWDPFIIIKARDMLKLLSRGVPAQEAI 101 Entamoeb...
Feature 1                  
4QMF_B               84 KIL 86  Saccharomyces cerevisiae S288C
5JPQ_GG             113 KIL 115 Chaetomium thermophilum
EQB61752             95 KVL 97  Nosema apis BRL 01
ELA48248             92 KVF 94  Vavraia culicis subsp. floridensis
WGS:AFBI:EDEG_01475  97 KIF 99  Edhazardia aedis USNM 41457
KCZ81349            100 EIF 102 Anncaliia algerae PRA339
ELP89164            101 KIL 103 Entamoeba invadens IP1
EHY65209            122 RVF 124 Nematocida sp. 1 ERTm2
ELA42474            110 KVL 112 Vittaforma corneae ATCC 50505
XP_654627           102 KVL 104 Entamoeba histolytica HM-1:IMSS

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap